解放军医学院学报2017，Vol.38Issue(9)：890-892,3.DOI:10.3969/j.issn.2095-5227.2017.09.023
软骨干细胞修复软骨损伤及治疗骨关节炎的研究进展
Research advance of cartilage-derived stem/progenitor cell in cartilage repair and its therapeutic potential in osteoarthritis
摘要
Abstract
Articular cartilage is a physiologically non-self-renewing avascular and nerveless tissue.Injury to cartilage often involves the whole joint,leading to development of degenerative joint diseases such as osteoarthritis (OA).Articular cartilage has been shown to contain a population of so-called cartilage-derived stem/progenitor cells (CSPCs),which are characterized by stem-cell related surface markers,clonogenicity and multilineage differentiation ability.The CSPCs are spontaneously aggregated and migrated to the damaged region to reconstruct the local microenvironment for repair.However,the origin and functions of CSPCs still remain unclear.Here we review the current status of CSPC research and discuss the possible role of cartilage stem cell may have in cartilage repair,and its therapeutic potential in OA.关键词
软骨干细胞/软骨损伤/骨关节炎Key words
cartilage stem cell/cartilage injury/osteoarthritis分类
医药卫生引用本文复制引用
袁雪凌,孟昊业,刘若西,王程,彭江,郭全义,汪爱媛,卢世璧..软骨干细胞修复软骨损伤及治疗骨关节炎的研究进展[J].解放军医学院学报,2017,38(9):890-892,3.基金项目
国家自然科学基金项目(51073024 （）
81472092 （）
81572148 （）
31640029):军队“十三五”医学专项(BWS13C029)Supported by the National Natural Science Foundation of China(51073024 （BWS13C029）
81472092 （）
81572148 （）
31640029) （）
The Special Project of the "Thirteenth Five-year Plan" for Medical Science Development of PLA (BWS13C029) （BWS13C029）
