解放军医学院学报2017，Vol.38Issue(10)：935-938,4.DOI:10.3969/j.issn.2095-5227.2017.10.008
血浆同型半胱氨酸水平与伴主动脉弓斑块隐源性脑卒中的相关性
Correlation between plasma homocystein level and cryptogenic ischemic stroke in patients with aortic plaques
李征 1赵秉清1
作者信息
- 1. 首都医科大学石景山教学医院北京市石景山医院神经内科二病区,北京 100043
- 折叠
摘要
Abstract
Objective To evaluate the association between plasma homocystein (Hcy) level and cryptogenic ischemic stroke (CIS),and analyze its clinical significance.Methods Patients with CIS and normal controls were consecutively recruited in the ward neurological department and outpatient department of Beijing Shijingshan Hospital to measure their plasma Hcy level by fluorescence polarization immunoassay and the severity of atherosclerotic plaques in carotid arteries and aortic arches were evaluated by ultrasonography.Results Thirty-two CIS patients and 47 normal controls were collected in total.The plasma Hcy level of CIS patients was significantly higher than that of normal controls [21.83 vs 15.73,P=0.005].Whereas,Hcy level failed to demonstrate an independent association with CIS after adjustment of confounding risk factors in multivariate logistic regression.Then all subjects were stratified by the presence of aortic or carotid plaques respectively.Then,plasma Hcy level was found to be an independent risk factor for CIS patients with aortic plaques (OR=1.55,95％CI:1.53-1.57,P=0.023) after adjusting confounding risk factors.Conclusion Hcy level shows association with CIS although Hcy level does not seem to be an independent risk factor for CIS;it is valuable to measure and control plasma Hcy level particularly in CIS patients with aortic plaques.关键词
缺血性脑卒中/同型半胱氨酸/主动脉斑块Key words
ischemic stroke/homocysteine/aortic plaques分类
医药卫生引用本文复制引用
李征,赵秉清..血浆同型半胱氨酸水平与伴主动脉弓斑块隐源性脑卒中的相关性[J].解放军医学院学报,2017,38(10):935-938,4.
