检验医学与临床2017，Vol.14Issue(22)：3297-3299,3.DOI:10.3969/j.issn.1672-9455.2017.22.007
血糖对PET/CT检查中脑肝摄取18F-FDG的影响
Effects of blood glucose on 18 F-FDG uptake by mesencephalic liver in PET/CT
摘要
Abstract
Objective To invetigate the effect and clinical application of blood glucose on 18 F-FDG brain liver uptake in positron emission tomagraphy(PET)/CT examination .Methods A total of 193 patients or individuals undergoing physical examination with PET/CT detection in the nuclear medicine department of the Handan Municipal Central Hospital from March 2014 to January 2016 were selected and divided into 3 groups according to the fasting blood glucose level ,helath group ,slightly high blood glucose group and high blood glucose group .The general data such as the age ,ses proportion ,body mass ,injection dose ,etc .had no statistical difference among 3 groups(P>0 .05) .The brain imagings were divided into the grade 0 ,1 ,2 and 3 from poor to good according to the imaging quality .The patients with brain and liver malignant tumor ,severe cerebral infarction or other contral nural system dis-eases ,liver dysfunctionand liver abscess affecting cerebral tissue or liver normal uptake were excluded .Results The brain and liver imaging rules were compared under different fasting blood glucose levels .The brain imaging quality had statistical difference be-tween the high blood glucose group with the health group and slightly higher blood glucose group (P<0 .05);approximately 30 %of brain tissue imaging quality showed the grade 0 ,with the blood glucose olevel decrease ,the proportion of brain tissue imaging quality grade 2 and 3 was elevated ;the proportion of grade 3 brain tissue imaging quality in the health group was significantly higher than that in the other two groups ;with the fasting blood glucose level increase ,the maximal standard uptake value of brain tissue on 18 F-FDG(SUVmax )was gradually decreased ,its value showed the invrse proportion with blood glucose level ;the liver SUVmax was in-creased with the fasting blood glucose increase .Conclusion Blood glucose level can influence the uptake of brain tissue and liver on 18 F-FDG .With the increase of blood glucose level ,the image quality of brain tissue and liver become worse ,otherwise ,higher quality images can be obtained .Therefore ,before conducting the 18 F-FDG PET/CT examination ,the patients correctly recognize and con-trol blood sugar level ,which has clinical application value for improving the 18 F-FDG PET/CT imaging quality and decreasing the misdiagnosis and missed diagnosis .关键词
血糖/生理性摄取/最大标准摄取值/阈值/肿瘤Key words
blood glucose/physiological uptake/SUVmax/threshold/tumor引用本文复制引用
刘春海,冯小伟,王海东,栗瑞敏,张云,陈永杰,杜文霞..血糖对PET/CT检查中脑肝摄取18F-FDG的影响[J].检验医学与临床,2017,14(22):3297-3299,3.基金项目
河北省医学科学研究重点课题资助项目(ZD20140063). （ZD20140063）
