检验医学与临床2017，Vol.14Issue(22)：3309-3310,3312,3.DOI:10.3969/j.issn.1672-9455.2017.22.011
影响结核分枝杆菌耐药的临床相关因素分析
Analysis of clinical related factors of drug resistance of Mycobacterium tuberculosis
摘要
Abstract
Objective To investigate the related factors of drug-resistant of Mycobacterium tuberculosis ,and to understand the drug resistance rate in the patients treated in this hospital and the potential risk factors of Mycobacterium tuberculosis infection to provide reference and basis for the prevention and treatment of tuberculosis (TB) .Methods The retrospective analysis was per-formed on 387 cases of TB receiving the therapy in this hospital from June 2015 to June 2016 ,and the data such as age and gender were collected for conducting the comparative analysis .The drug susceptibility test of clinically isolated bacterial strains was con-ducted by adopting the proportion method ;the drug resistance of different strains was observed and compared .The univariate non-conditional Logistic regression analysis was adopted to analyze the drug resistance related factors of Mycobacterium tuberculosis . Results Among 387 cases of TB ,total drug resistance rate was 43 .82% ,in which the single drug resistance rate ,the multi-drug re-sistance rate and pan-drug resistance rates were 13 .41% ,24 .74% and 5 .66% respectively ;the initial treatment drug resistance rate was 56 .11% .The re-treatment drug resistant rate was 30 .88% ;the drug resistance situation had no statistical difference among different patients with complication diabetes (P>0 .05);the drug resistance had no statistical difference in gender ,smoking history , TB treatment history among different patients(P<0 .05);the drug resistance rate of male patients was higher than that of female patients ,the difference was statistically significant (P<0 .05);the drug resistant rate in the patients with complicating diabetes was higher than that in the patients without complicating diabetes ,but the difference was not statistically significant (P>0 .05);the drug resistant rate in the patients with smoking history was higher than that in the patients without smoking history ,difference was sta-tistically significant(P<0 .05);the drug resistant rate in the patients without TB treatment history was lower than that in the pa-tients with Tb treatment history ,the difference was statistically significant (P<0 .05) .The univariate non-conditional Logistic re-gression analysis showed that the TB treatment history was the risk factor for TB patients developing drug resistance . Conclusion The TB treatment history and smoking history are the risk factors of drug resistance occurrence in TB patients .The in-fluence factors in different patients generating drug resistance exist difference ,therefore clinic should strengthen the prevention and control of drug resistant Mycobacterium tuberculosis .关键词
结核分枝杆菌/耐药/回归分析Key words
Mycobacterium tuberculosis/drug resistance/regression analysis引用本文复制引用
万东勇,胡永芳,陈天刚..影响结核分枝杆菌耐药的临床相关因素分析[J].检验医学与临床,2017,14(22):3309-3310,3312,3.基金项目
重庆市卫生计生委中医药管理局科研计划资助项目(2008-2-293). （2008-2-293）
