检验医学与临床2017，Vol.14Issue(22)：3323-3327,5.DOI:10.3969/j.issn.1672-9455.2017.22.017
fas基因启动子区多态性与乳腺癌发病风险关系的Meta分析
Relationship between fas gene promoter polymorphisms and breast cancer onset risk :a meta analysis
摘要
Abstract
Objective To systematically evaluate the relationship between fas gene promoter region(-1377 G/A and-670 A/G) polymorphisms and breast cancer onset risk .Methods The electronic databases of PubMed ,Embase ,Web of Science ,CNKI ,Wan-fang Data and CBM were retrieved until to expiration date February 10 ,2017 .The literatures were screened according to the inclu-sion and exclusion standard .The meta analysis was performed by using the Stata 13 .0 software .The publication bias was evaluated and sensitivity analysis was also performed .Results A total of 11 studies were included .The combined results showed that there was no association between fas gene promoter region(-1377 G/A and-670 A/G)polymorphisms and breast cancer onset risk .The Egger′s linear regression analysis revealed that no publication bias existed (P>0 .05) .After getting rid of studies one by one ,it was found that meta analysis results received little influence by single study .Conclusion fas gene promoter region(-1377 G/A and-670 A/G)polymorphisms may have no association with breast cancer onset risk .关键词
乳腺癌/fas基因/多态性/Meta分析/对照研究Key words
breast cancer/fas/polymorphisms/meta-analysis/case-control study引用本文复制引用
张晓燕,杨波,朱妙仪,刘彦慧..fas基因启动子区多态性与乳腺癌发病风险关系的Meta分析[J].检验医学与临床,2017,14(22):3323-3327,5.基金项目
广东省东莞市社会科技发展项目(201550725000094 ,东科〔2015〕202号). （201550725000094 ,东科〔2015〕202号）
