临床小儿外科杂志2017，Vol.16Issue(5)：473-477,5.DOI:10.3969/j.issn.1671-6353.2017.05.013
东莨菪碱改善先天性室间隔缺损合并肺动脉高压患儿体外循环术后氧合指数的效果探讨
Improving effects of scopolamine on oxygenation index in children with ventricular septal defect and pulmonary hypertension after cardiac surgery
卢圣勋 1罗俊辉 1邢亚闯 1范义兵 1张娜 1吴青华2
作者信息
- 1. 解放军第150中心医院心血管外科 河南省洛阳市,471031
- 2. 解放军第150中心医院麻醉科 河南省洛阳市,471031
- 折叠
摘要
Abstract
Objective To detect the improving effect of scopolamine on oxygenation index ( OI, PaO2/FiO2 ) in children with congenital ventricular septal defect ( VSD) and pulmonary hypertension ( PH) after car.diopulmonary bypass. Methods A total of 49 VSD/PH children were randomly divided into treatment (n=26) and control (n=23) groups. In treatment group, at 30 min before anesthesia, there was an intramuscular injection of scopolamine 0. 01 mg·kg-1 and followed by a continuous intravenous infusion of scopolamine at the end of operation (an initial dose 0. 03~0. 05 mg·kg-1·h-1). In control group, scopolamine was not used. The re.maining schedules were the same. The values of average OI within 6h post-operation, average peak airway pres.sure, mechanical ventilation time (MVT) and OI post-extubation were monitored, compared and used for evaluating the curative effect of scopolamine. Results Two cases were removed out of treatment group. Compared with monitoring values of control group, the average OI of treatment group significantly increased within 6h post.operation (268. 5 ± 58. 0 vs. 233. 5 ± 40. 8 mmHg, P<0. 05). No significant difference existed in average peak air-way pressure (21.2 ±2.2 vs. 22.0 ±3.2 cmH2O, P>0.05). MVT (13.7 ±7.9 vs. 19.7 ±13.0h,P<0.05) and OI post-extubation (285. 0 ± 32. 3 vs. 243. 7 ± 40. 1 mmHg, P<0. 05) obviously improved in treatment group. Drug adverse reactions:there were 2 cases of abdominal distension. Conclusion An optimal amount of scopolamine may improve OI and shorten the duration of mechanical ventilation in VSD/PH children after CPB.关键词
室间隔缺损/高血压,肺性/东莨菪碱/体外循环Key words
Heart Septal Defects/Ventricular/Hypertension/Pulmonary/Scopolamine/Extracorporeal Circulation引用本文复制引用
卢圣勋,罗俊辉,邢亚闯,范义兵,张娜,吴青华..东莨菪碱改善先天性室间隔缺损合并肺动脉高压患儿体外循环术后氧合指数的效果探讨[J].临床小儿外科杂志,2017,16(5):473-477,5.
