临床与实验病理学杂志2017，Vol.33Issue(7)：728-732,5.DOI:10.13315/j.cnki.cjcep.2017.07.005
涎腺腺样囊性癌中HIF-1α和BCL-2的表达及意义
Expression of HIF-1α and BCL-2 in salivary adenoid cystic carcinoma and its clinical significance
摘要
Abstract
Purpose To investigate the relationship of HIF-1α,BCL-2 and clinicopathological features in salivary adenoid cystic carcinoma by detecting the levels of two proteins.Methods Immunohistochemical of SP staining assay was used to detect the level of HIF-1α and BCL-2 expression in fifty-six section from primary resection of salivary adenoid cystic carcinoma.Furthermore,the correlation between the expressions of two proteins with clinical data was evaluated through differently statistical analysis.Results Thirty-six samples (64.3％) were found to express HIF-1α.The level of HIF-1α was significantly correlated with TNM stage of tumors and the primary site of salivary adenoid cystic carcinoma (P ＜ 0.05).Positive BCL-2 expression was detected in fifty-five cases (98.2％).The level of HIF-1 α was positively correlated with that of BCL-2 (P ＜ 0.05)and the significant correlation between HIF-1α and TNM stage was dependent upon the strong expression of BCL-2 (P ＜ 0.05).Conclusion It is therefore indicated that the expression of HIF1α and BCL-2 may influence the clinical stage of salivary adenoid cystic carcinoma.关键词
涎腺肿瘤/腺样囊性癌/HIF-1α/BCL-2/免疫组织化学Key words
salivary neoplasm/adenoid cystic carcinoma/HIF-1 α/BCL-2/immunohistochemistry分类
医药卫生引用本文复制引用
鲍合刚,肖亮,孟刚,王岳君,王芬,金问森..涎腺腺样囊性癌中HIF-1α和BCL-2的表达及意义[J].临床与实验病理学杂志,2017,33(7):728-732,5.基金项目
国家自然科学基金(U1432124) （U1432124）
