临床与实验病理学杂志2017，Vol.33Issue(7)：773-777,5.DOI:10.13315/j.cnki.cjcep.2017.07.015
肾脏横纹肌样滑膜肉瘤1例并文献复习
Renal rhabdoid synovial sarcoma: report of a case with literature review
摘要
Abstract
Purpose To report a rare case of renal rhabdoid synovial sarcoma and review the literature,in order to improve the realization for this disease and reduce misdiagnosis.Method The clinicopathological data of 1 case rhabdoid renal synovial sarcoma were retrospectively analyzed.The tumors were examined by immunohistochemical of EnVision two-step staining and FISH,the related literatures were reviewed.Result A 31-year-old male patient accepted the right kidney radical operation in November 2014 after imaging examination of right kidney tumor.Microscopically,the tumor cells showed short spindle cells with rich cytoplasm and eosinophilic bodies in the cytoplasm.The pathological diagnosis is the renal rhabdoid tumor for this time.The patient was found a tumor between the liver and the diaphragm by imaging examination in October 2015.The second operation was carried out successfully.Microscopically,the tumor cells were spindle with little cytoplasm and without eosinophilic bodies in the cytoplasm.It was a typical synovial sarcoma in morphology for this time.Immunohistochemical staining showed positive for vimentin,EMA,CD56,and TLE1,SS18SSX fusion gene was disclosed in the primary and recurrent tumor cells,it was therefore corrected as rhabdoid synovial sarcoma for the primary tumor.Conclusion Renal rhabdoid synovial sarcoma is rare.Renal primary rhabdoid synovial sarcoma is easily misdiagnosed as renal rhabdoid tumor.The renal rhabdoid synovial sarcoma has broadened the differential diagnosis of renal rhabdoid tumors spectrum.Even for a tumor with typical rhabdoid morphology,molecular biology method for differential diagnosis is needed.SS18-SSX fusion gene is the basis for diagnosis of synovial sarcoma.关键词
肾脏肿瘤/滑膜肉瘤/横纹肌样/免疫组织化学/融合基因Key words
renal neoplasm/synovial sarcoma/rhabdoid/immunohistochemistry/fusion gene分类
医药卫生引用本文复制引用
袁伟,陈伶俐,侯英勇,侯君,纪元,曾海英,黄洁..肾脏横纹肌样滑膜肉瘤1例并文献复习[J].临床与实验病理学杂志,2017,33(7):773-777,5.基金项目
上海市卫计委薄弱科室项目(2015ZB0201)、复旦大学附属中山医院青年基金(2015ZSQN17) （2015ZB0201）
