临床与实验病理学杂志2017，Vol.33Issue(8)：841-846,6.DOI:10.13315/j.cnki.cjcep.2017.08.004
Arginase-1联合Glypican-3在肝细胞肝癌和非肝脏来源肿瘤鉴别诊断中的意义
Significance of Arginase-1 and Glypican-3 in differential diagnosis of hepatocellular carcinoma from non-hepatocellular carcinoma
周新刚 1张亮 1王鹏 1滕晓英 1孙磊 1马志园 1刘红刚2
作者信息
- 1. 首都医科大学附属北京地坛医院病理科,北京 100015
- 2. 首都医科大学附属北京同仁医院病理科,北京100730
- 折叠
摘要
Abstract
Purpose To evaluate the expression of Arginine-1 (Arg-1) and Glypican-3 (GPC-3) in hepatocellular carcinoma (HCC) and non-hepatocellular carcinoma,as well as to summarize the related researches.Methods 156 cases of HCC,5 cases of cholangiocarcinoma,20 cases of metastatic adenocarcinoma and 18 cases of other types of tumors were studied.Immunohistochemical study for Arg-1 and GPC-3 was performed on the formalin-fixed and paraffin-embedded tumor tissues.Results The positive expression rates of Arg-1 in HCC and non-hepatocellular carcinoma were 93.6％ (146/156) and 0 (0/43),respectively,meanwhile the expression rate decreased with decreasing of differentiation (r =-0.264,P =0.001).GPC-3 expression was observed in 141 of 156 cases of HCC (90.4％) and 6 of 43 cases of non-hepatocellular carcinoma (14％),and the expression rate increased with decreasing of differentiation (r =0.179,P =0.026).The sensitivity,specificity,positive predictive value and negative predictive value of Arg-1 and GPC-3 in distinguishing HCC from non-hepatocellular carcinoma were 93.6％,100％,100％,81.1％ and 90.4％,86％,96.0％,71.2％,respectively.Conclusion Arg-1 is a sensitive and specific marker of hepatocytes.The application of Arg-1 and GPC-3 is of great significance in diagnosis of HCC and liver metastatic adenocarcinoma.关键词
肝肿瘤/肝细胞肝癌/精氨酸酶-1/磷脂酰肌醇蛋白聚糖-3Key words
liver neoplasms/hepatocellular carcinoma/Arginase-1/Glypiean-3分类
医药卫生引用本文复制引用
周新刚,张亮,王鹏,滕晓英,孙磊,马志园,刘红刚..Arginase-1联合Glypican-3在肝细胞肝癌和非肝脏来源肿瘤鉴别诊断中的意义[J].临床与实验病理学杂志,2017,33(8):841-846,6.
