临床与实验病理学杂志2017，Vol.33Issue(8)：896-900,5.DOI:10.13315/j.cnki.cjcep.2017.08.014
原发性肺淋巴上皮瘤样癌20例临床病理分析
Primary pulmonary lymphoepithelioma-like carcinoma: a clinicopathological analysis of twenty cases
李雯 1康德勇 1杨映红1
作者信息
- 1. 福建医科大学附属协和医院病理科,福州350001
- 折叠
摘要
Abstract
Purpose To study the clinicopathological characteristics,treatments and prognosis of primary pulmonary lymphoepithelioma-like carcinoma (LELC).Methods Twenty cases of LELC were collected and the clinicopathological characteristics,immunohistochemical expression,survival data and clinical treatments were analyzed,with review of the literatures.Resuits Histopathologically,it was characterized by the syncytial pattern of growing with large vesicular nuclei,conspicuous nucleoli,and a marked lymphocytic infiltrate in the stroma that was similar to undifferentiated nasopharyngeal carcinoma.The immunohistochemical staining of CKpan showed positive expression in all cases (100％).Also the positive expression of in situ hybridization of Epstein-Bar virus-encoded RNA (EBER) were in all cases (100％) while the positive cases of CK5/6,p63 and p40 were 19,18,and 16 respectively.But gene mutations such as EGFR,K-RAS were negative.All the LELC patients in this cohort were survived until the deadline of follow-up.Comprehensive treatments were done such as surgical resection,radiotherapy and chemotherapy.Conclusion Primary pulmonary LELC is a rare disease that histomorphological analysis and immunohistochemistry are the main methods of diagnosis for it.It must be excluded the metastasis carcinoma from other locations.While both EGFR mutation and anaplastic lymphoma kinase (ALK)mutation could be commonly detected in non-small cell lung cancer,but seldom in LELC of lung.The high expression of PD1/PD-L1 may provide a rationale for immunotherapy in this subtype of lung cancer.Currently,experimental therapy is still taken in the pulmonary LELC.关键词
肺肿瘤/淋巴上皮瘤样癌/临床病理/基因突变Key words
lung neoplasms/lymphoepithelioma-like carcinoma/clinicopathology/gene mutation分类
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李雯,康德勇,杨映红..原发性肺淋巴上皮瘤样癌20例临床病理分析[J].临床与实验病理学杂志,2017,33(8):896-900,5.
