临床与实验病理学杂志2017，Vol.33Issue(9)：945-949,5.DOI:10.13315/j.cnki.cjcep.2017.09.001
卵巢癌中Tiam1蛋白过表达的临床病理学意义
Clinical implication of Tiam1 protein overexpression in ovarian carcinoma
摘要
Abstract
Purpose To investigate the clinicopathological significance of Tiam1 overexpression in ovarian carcinoma.Methods Tiam1 protein was detected in 98 serous carcinomas,64 ovarian mucinous cystadenocarcinomas and 27 benign ovarian tumors using immunohistochemical of SP two-step staining.Correlations between Tiam1 overexpression and clinicopathological features of ovarian carcinoma were evaluated.Overall survival and disease-free survival rates of ovarian carcinoma patients were calculated by Kaplan-Meier method.Results Tiam1 protein showed a cytoplasmic and nuclear staining pattern in ovarian carcinoma.The positive rate and strongly positive rate of Tiam1 protein were 84.7％ (83/98)and 70.4％ (69/98)in serous carcinoma,the positive rate and strongly positive rate of Tiam1 protein were 87.5％ (56/64) and 73.4％ (47/64) in ovarian mucinous cystadenocarcinoma,both of which were significantly higher than those in benign ovarian tumor (both P ＜ 0.01).High-level expression of Tiam1 was positively correlated with the histological grade,FIGO stage,and metastasis in ovarian carcinoma (both P ＜ 0.05),while independent of age and menopausal status (both P ＞ 0.05).Kaplan-Meier survival analysis showed that overall survival and disease-free survival of ovarian cancer patients with high expression of Tiam1 protein were significantly lower than those of patients with lower expression of Tiam1 protein (P ＜ 0.05),overall survival in metastatic ovarian cancer patients with high expression of Tiam1 protein was significantly lower than those in patients with low Tiam1 protein expression (P ＜ 0.05).Conclusion Tiam1 expression is significantly high in ovarian carcinoma.Tiam1 protein is closely associated with ovarian carcinoma progression,which may be a new potential prognostic biomarker and a therapeutic target for ovarian carcinoma.关键词
卵巢肿瘤/Tiam1/免疫组织化学/预后/生存分析Key words
ovarian neoplasm/Tiam1/immunohistochemistry/prognosis/survival analysis分类
医药卫生引用本文复制引用
杨洋,孙洁,朱光,朴俊杰,林贞花..卵巢癌中Tiam1蛋白过表达的临床病理学意义[J].临床与实验病理学杂志,2017,33(9):945-949,5.基金项目
国家自然科学基金(61371067) （61371067）
