国际眼科杂志2017，Vol.17Issue(12)：2304-2307,4.DOI:10.3980/j.issn.1672-5123.2017.12.28
糖尿病视网膜病变患者血清VEGF、ES、TKLK、TSP、sICAM-1水平的变化及意义
Changes and significance of serum levels of VEGF, ES, TKLK, TSP and sICAM-1 in patients with diabetic retinopathy
胡利梅 1闫武超 2任卫东 1刘慧颖 1邓文娟 1许峥嵘 1左丽娟 1谷君 1史丽1
作者信息
- 1. 075000 中国河北省张家口市,河北北方学院附属第一医院内分泌科
- 2. 075000 中国河北省张家口市眼科医院功能科
- 折叠
摘要
Abstract
·AIM: To investigate the changes of serum levels of vascular endothelial growth factor ( VEGF ) , Endostatin (ES), thrombospondin (TSP), tissue kallikrein (TKLK) and soluble intercellular adhesion molecule-1 ( sICAM-1) in patients with diabetic retinopathy ( DR ) and its clinical significance.·METHODS:Selected 60 patients with non-proliferative diabetic retinopathy ( NPDR group ) , 60 patients with proliferative diabetic retinopathy ( PDR group ) were enrolled in this study. Sixty diabetic patients without diabetic retinopathy ( DM group ) and 60 healthy people ( control group) were also enrolled. Collection time was from January 2014 to December 2016. Serum levels of VEGF, ES, TSP, TKLK and sICAM-1 were measured and compared.·RESULTS: The levels of serum VEGF, TKLK and sICAM-1 in PDR group were significantly higher than those in NPDR group, DM group and control group ( P<0. 05). The ES of PDR group was significantly lower than that of NPDR group, DM group and control group ( P<0. 05). The levels of VEGF, TKLK and ES in the NPDR group were significantly higher than those in the DM group and the control group (P<0. 05). The serum VEGF in the NPDR group was positively correlated with the levels of ES, TKLK and sICAM-1 (P<0. 05). The serum VEGF of PDR group was positively related to the levels of TKLK and sICAM-1 (P<0. 05). There was no significant relationship between serum VEGF with ES and TSP in PDR group (P>0. 05).·CONCLUSION: The levels of serum ES, TSP, TKLK and sICAM - 1 in patients with DR have changed significantly, and the process of retinopathy has been affected by regulating the level of VEGF.关键词
血管内皮细胞生长因子/内皮抑素/血小板反应蛋白/组织激肽释放酶/可溶性细胞间黏附分子-1/糖尿病视网膜病变Key words
vascular endothelial growth factor/endostatin/platelet reactive protein/tissue kallikrein/soluble intercellular adhesion molecule - 1/diabetic retinopathy引用本文复制引用
胡利梅,闫武超,任卫东,刘慧颖,邓文娟,许峥嵘,左丽娟,谷君,史丽..糖尿病视网膜病变患者血清VEGF、ES、TKLK、TSP、sICAM-1水平的变化及意义[J].国际眼科杂志,2017,17(12):2304-2307,4.
