南京医科大学学报（自然科学版）2017，Vol.37Issue(10)：1362-1368,7.DOI:10.7655/NYDXBNS20171034
DENND1A基因多态性与多囊卵巢综合征易感性的Meta分析
Meta-analysis on relationship between DENND1A polymorphisms and polycystic ovary syndrome
彭丹红 1罗嘉莉 2凌丽 2李雪琳 2任慕兰2
作者信息
- 1. 东南大学附属中大医院妇产科,江苏南京210009
- 2. 东南大学医学院,江苏南京210009
- 折叠
摘要
Abstract
Objective:To explore the association between DENND1A polymorphisms and polycystic ovary syndrome (PCOS).Methods:The relevant studies were identified through a search of PubMed,Excerpta Medica Database (Embase),etc.until Jan 2016.The association between DENND1A polymorphisms and polycystic ovary syndrome risk was assessed by odds ratios(ORs) together with their 95％ confidence intervals (CIs).Results:A total of eight studies were eventually identified for DENND1A.We found a significant association between DENND 1A rs 10818854,rs2479106 and rs 10986105 polymorphisms and PCOS susceptibility in overall population.In subgroup analysis,similar results were found in Asian[OR(95％CI)＞1.00,P＜0.05],while in Caucasian,no significant association was detected between rs2479106 and PCOS (P＞0.05).Conclusion:The present meta-analysis suggests that DENND1A rs10818854,rs2479106,rs10986105 polymorphisms may be associated with polycystic ovary syndrome susceptibility,but there are ethnic differences.All these three polymorphisms are risk factors for Asians:while in Caucasian,rs2479106 is not related to polycystic ovary syndrome susceptibility.Further large and well-designed studies are needed to confirm this association.关键词
DENND1A基因/多囊卵巢综合征/基因多态性/Meta分析Key words
DENND 1A/polycystic ovary syndrome/polymorphism/meta-analysis分类
医药卫生引用本文复制引用
彭丹红,罗嘉莉,凌丽,李雪琳,任慕兰..DENND1A基因多态性与多囊卵巢综合征易感性的Meta分析[J].南京医科大学学报（自然科学版）,2017,37(10):1362-1368,7.
