四川医学2017，Vol.38Issue(8)：938-941,4.DOI:10.16252/j.cnki.issn1004-0501-2017.08.023
预测局部进展期直肠癌新辅助放化疗后病理完全缓解的临床因素研究
Clinical Study on Predicting Pathologic Complete Response after Neoadjuvant Chemoradiotherapy for Locally Ad-vanced Rectal Cancer
胡海 1燕锦 1刘超 1徐琳 1宋博 1周海洋 1张轲 1易波 1郑阳春1
作者信息
- 1. 四川省肿瘤医院 研究所胃肠外科中心,四川省癌症防治中心,电子科技大学医学院,四川 成都610041
- 折叠
摘要
Abstract
Objective To explore clinical parameters that could predict pathologic complete response(pCR) after neoad-juvant chemoradiotherapy for locally advanced rectal cancer.Methods The retrospective study involved 53 patients with locally advanced rectal cancer,who underwent neoadjuvant chemoradiotherapy followed by surgery between October 2013 and September 2016.Univariate analysis and multivariate logistic regression analysis were performed to identify clinical factors associated with pCR.Results Among 53 patients,11(20.8%)achieved pCR status.Univariate analysis found that neoadjuvant chemotherapy reg-imens(P=0.019) and age(P=0.048) were significantly correlated with pCR.Multivariate logistic regression analysis revealed that neoadjuvant chemotherapy regimens(OR=0.078,P=0.045) was the unique independent predictor of pCR.Conclusion Neoadjuvant chemotherapy with oxaliplatin and fluorouracil after neoadjuvant chemoradiotherapy for locally advanced rectal cancer achieved high rate of pCR.关键词
直肠肿瘤/新辅助放化疗/病理完全缓解/预测Key words
rectal neoplasms/neoadjuvant chemoradiotherapy/pathologic complete response/predictor分类
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胡海,燕锦,刘超,徐琳,宋博,周海洋,张轲,易波,郑阳春..预测局部进展期直肠癌新辅助放化疗后病理完全缓解的临床因素研究[J].四川医学,2017,38(8):938-941,4.
