四川医学2017，Vol.38Issue(9)：1063-1065,3.DOI:10.16252/j.cnki.issn1004-0501-2017.09.024
EMA-CO方案治疗21例耐药滋养细胞肿瘤的疗效分析
Efficacy of EMA-CO Regimen in the Treatment of 21 Patients with Drug-resistant Trophoblastic Tumors
何文静 1谢兰 1周毅1
作者信息
- 1. 四川省人民医院妇产科,四川成都610072
- 折叠
摘要
Abstract
Objective To investigate the efficacy of EMA-CO regimen in the treatment of drug-resistant gestational trophoblastic tumor(GTN).Methods The clinical efficacy and side effects of EMA-CO regimen in the treatment of GTN resistant patients with first-line 5-FU single drug chemotherapy regimen were retrospectively reviewed in 21 cases treated in Sichuan Provincial People's Hospital from October 2005 to October 2015.Results The cure rate of EMA-CO regimen for resistant GTN was up to 90.48％.The main adverse reactions were bone marrow suppression,gastrointestinal reactions and mild liver damage.Among them,bone marrow suppression of degree Ⅲ accounted for 9.57％,bone marrow suppression of degree Ⅳ accounted for 3.19％,digestive tract reaction of degree Ⅰ-Ⅱ accounted for 39.36％,liver function damage of degree Ⅰ-Ⅱ accounted for 13.83％,and the rest of patients did not have serious complications.Conclusion The EMA-CO regimen has definite efficacy,mild side effects,and is easy to accept as a preferred chemotherapy regimen for drug-resistant GTN,关键词
妊娠滋养细胞肿瘤/抗药性/化疗/EMA-CO方案Key words
gestational trophoblastic tumor/drug resistance/chemotherapy/eMA-CO regimen分类
医药卫生引用本文复制引用
何文静,谢兰,周毅..EMA-CO方案治疗21例耐药滋养细胞肿瘤的疗效分析[J].四川医学,2017,38(9):1063-1065,3.
