肿瘤预防与治疗2017，Vol.30Issue(4)：254-260,7.DOI:10.3969/j.issn.1674-0904.2017.04.003
393例ⅠB1～ⅡA2期子宫颈癌患者的临床病理与预后分析
The Clinical and Prognostic Analysis of 363 Cases of Stage ⅠB1 ～ ⅡA2 Cervical Cancer
王登凤 1石宇 1张国楠 1裴姣 2史洵玮1
作者信息
- 1. 610041 成都,四川省肿瘤医院·研究所,四川省癌症防治中心,电子科技大学医学院 妇科肿瘤中心
- 2. 610041 成都,四川省肿瘤医院·研究所,四川省癌症防治中心,电子科技大学医学院 临床研究中心
- 折叠
摘要
Abstract
Objective:To investigate prognosis-related clinicopathologic factors in early stage cervical cancer patients.Methods:Stage ⅠB1 ～ Ⅱ A2 cervical cancer patients who accepted surgical treatment in our center between Nov.1 st,2009 and Oct.31 th,2014 were included in this study.The clinicopathologic and prognostic data of all the patients were analyzed retrospectively.Results:A total of 393 patients were followed up until Dec.31th,2016 with a follow-up rate of 92.37％ (363/393).The median age was 45 years old,with a peak age between 40 and 50 years.The recurrence-free survival rate was 90.63％ (329/363),the recurrence rate was 2.48％ (9/363) and the mortality rate was 6.89％ (25/363).The 5-year overall survival (OS) rate and disease free survival (DFS) rate was 92％ and 89％,respectively.The result of Cox's proportional hazard regression analysis showed that FIGO stage,histopathological type,and depth of cervical stromal invasion were related with OS.In addition,the first two factors were also related with DFS(P ＜ 0.05).Conclusion:Cervical cancer typically occurs between 40 and 50 years of age.The most common histopathological type is cervical squamous carcinoma.FIGO stage,histopathological type,and depth of cervical stromal invasion are independent prognostic factors.Although perineural invasion (PNI) is not an independent poor prognostic factor,it is closely related with lymph node metastasis (LNM).Furthermore,as neoadjuvant chemotherapy may cause false-negative result of some risk factors,appropriate broadening of the indications of postoperative adjuvant radiotherapy and chemotherapy is recommended.关键词
宫颈肿瘤/妇科外科手术/放化疗/预后Key words
Uterine cervical neoplasms/Gynecologic surgical procedures/Chemoradiotherapy/Prognosis分类
医药卫生引用本文复制引用
王登凤,石宇,张国楠,裴姣,史洵玮..393例ⅠB1～ⅡA2期子宫颈癌患者的临床病理与预后分析[J].肿瘤预防与治疗,2017,30(4):254-260,7.
