山东中医药大学学报2017，Vol.41Issue(6)：540-542,3.
大柴胡汤加减联合醋酸奥曲肽注射液治疗重症急性胰腺炎临床研究
Clinical Study on Modified Dachaihu Decoction Combined with Octreotide Acetate Injection in Treatment of Severe Acute Pancreatitis
摘要
Abstract
Objective:To observe the effects of Dachaihu decoction combined with octreotide acetate injection on the inflammatory factors and intestinal mucosal barrier function in patients with severe acute pancreatitis. Methods:Total 82 patients with severe acute pancreatitis were randomly divided into the observation group and the control group with 41 patients in each group according to the time of admission. Two groups were given fasting,rehydration,anti-inflammatory and other basic treatments. The observation group received Dachaihu decoction combined with octreotide acetate injection treatment while the control group was given octreotide acetate injection 25μg/h,continuous intravenous pumping. The serum inflammatory factors,intestinal mucosal barrier function and clinical treatment effects were observed. Results:The effective rate of the observation group was 95.12%,significantly higher than that of the control group(82.93%)(P<0.05). The levels of interleukin-6(IL-6),interleukin-8(IL-8) and serum tumor necrosis factor(TNF-α) in the observation group were significantly lower than those in the control group(P<0.05). Plasma two amine oxidase(DAO) concentration,lactulose/mannitol ratio(L/M) and endotoxin in the observation group were significantly lower than those in the control group(P<0.05). Period of time until subsidence of abdominal distension,period of time until subsidence of abdominal pain,period of time until relieving nausea and vomiting,the initial defecation time and the duration of hospitalization in the observation group were significantly lower than those in the control group ( P<0 . 05 ) . Conclusion:Dachaihu decoction combined with octreotide acetate injection can improve the therapeutic effects.关键词
重症急性胰腺炎/醋酸奥曲肽注射液/大柴胡汤/炎性因子/肠黏膜屏障功能Key words
severe acute pancreatitis/octreotide acetate injection/Dachaihu decoction/inflammatory factor/intestinal mucosal barrier function分类
医药卫生引用本文复制引用
解淑萍,张新,曹志群,王雪艳,康玉华..大柴胡汤加减联合醋酸奥曲肽注射液治疗重症急性胰腺炎临床研究[J].山东中医药大学学报,2017,41(6):540-542,3.基金项目
山东中医药大学附属医院课题(编号:省中科字[2011]2010号) （编号:省中科字[2011]2010号）
