山东中医药大学学报2017，Vol.41Issue(6)：561-564,4.
滋阴固本方对急性EAE模型大鼠脊髓损伤后Nogo-A蛋白表达的影响
Effects of Ziyin Guben Prescription on Expressions of Nogo-A in Rats with Acute Spinal Cord Injury Due to Experimental Autoimmune Encephalomyelitis
摘要
Abstract
Objectives:To observe the effects of Ziyin Guben prescription on the expressions of Nogo-A in rats with acute spinal cord injury due to experimental autoimmune encephalomyelitis(EAE). Methods:Total 72 female wistar rats were randomly divided into 6 groups by random digits table to establish the EAE model,observing the rats weight,food intake,neurobehavioral changes and the corresponding score,patholog-ical changes of the spinal tissue and the expression of Nogo-A in spinal tissue. Results:Neurobehavioral changes of rats:Compared with the model group,each Chinese medicine group can decrease the incidence, relieve the clinical symptoms and reduce the weight loss(P<0.01). There was statistical significance between the low dose group and the medium-high dose groups of Chinese medicine in the neural function score (P<0.01). The immunohistochemistry results showed:the expression of Nogo-A protein in the model group was positive while the expressions in the hormone group and the medium-high dose groups of Chinese medicine were reduced(P<0.01),there were statistical significance between the low,medium and high dose groups of Chinese medicine(P<0.01). Conclusion:Ziyin Guben prescription could inhibit the expression of Nogo-A in the acute stage to repair the nervous system.关键词
滋阴固本方/实验性自身免疫性脑脊髓炎/多发性硬化/轴突生长抑制因子蛋白/大鼠Key words
Ziyin Guben prescription/experimental autoimmune encephalomyelitis/multiple sclerosis/Nogo-A protein/rat分类
医药卫生引用本文复制引用
张玲燕,文凯华,王宝亮..滋阴固本方对急性EAE模型大鼠脊髓损伤后Nogo-A蛋白表达的影响[J].山东中医药大学学报,2017,41(6):561-564,4.基金项目
河南省高等学校重点科研项目(编号:13A360577) （编号:13A360577）
