山东医药2017，Vol.57Issue(41)：28-30,3.DOI:10.3969/j.issn.1002-266X.2017.41.008
口腔鳞状细胞癌组织中Twist、E-cadherin蛋白的表达变化及意义
Expression changes of Twist and E-cadherin in oral squamous cell carcinoma
摘要
Abstract
Objective To explore the expression changes of the transcription factor Twist and the E-cadherin in the o-ral squamous cell carcinoma (OSCC)tissues and to investigate the clinical significance. Methods The immunohisto-chemical SP method was used to detect the expression levels of the Twist and E-cadherin in 65 cases of OSCC tissues and 45 cases of oral normal mucosa tissues. In addition,the relationship between the expression of Twist/ E-cadherin and the clinicpathologic characteristics was analyzed,and the Spearman was used to explore the correlation between the Twist and E-cadherin in OSCC tissues. Results The positive expression rates of Twist in the OSCC tissues and oral normal mucosa tissues were 72. 31% (47 / 65)and 11. 11% (5 / 45),respectively (P < 0. 05). The positive expression rates of E-cadher-in in the OSCC tissues and oral normal mucosa tissues were 23. 08% (19 / 65)and 86. 67% (39 / 45),respectively (P <0. 05). The Twist and E-cadherin expression levels in the OSCC tissues were related with the lymph node metastasis and the clinical stages (both P < 0. 05),but were not related with the gender,age,differentiation degree and the type (all P >0. 05). The expression of Twist and E-cadherin was negatively correlated in the OSCC tissues (r = - 0. 412,P < 0. 05). Conclusions The transcription factor Twist is up-regulated and E-cadherin is down-regulated,both of them play a critical role in the occurrence and malignant progression of OSCC.关键词
口腔鳞状细胞癌/转录因子Twist/上皮细胞钙黏蛋白Key words
oral squamous cell carcinoma/transcription factor Twist/E-cadherin分类
医药卫生引用本文复制引用
王陈飞,冯桂娟,王继华,冯兴梅..口腔鳞状细胞癌组织中Twist、E-cadherin蛋白的表达变化及意义[J].山东医药,2017,57(41):28-30,3.基金项目
江苏省卫生和计划生育委员会资助科研项目(H201678). （H201678）
