山东医药2017，Vol.57Issue(43)：5-7,3.DOI:10.3969/j.issn.1002-266X.2017.43.002
老年轻度认知功能障碍患者血清25-羟维生素D水平变化及其临床意义
Change and clinical value of serum 25-hydroxyvitamin D level in elderly patients with mild cognitive impairment
摘要
Abstract
Objective To investigate the change and clinical value of serum 25-hydroxyvitamin D [25(OH)D]level in the elderly patients with mild cognitive impairment (MCI)as compared with those with normal cognition (NC). Meth-ods Totally 148 elderly patients were selected. Cognitive function was assessed by Peking Union Medical College Hospital vision of Montreal Cognitive Assessment (MoCA-P). According to the criteria of MCI revised in 2003 by the international work group [National Institute of Neurological Disorders and Stroke (NINDS)and Association Internationale pour la Re-cherche et l'Enseignement en Neurosciences (AIREN)],the 148 elderly patients were divided into two groups:NC group and MCI group. The serum 25(OH)D levels were detected and compared between the two groups. The relationship be-tween the MCI and serum 25(OH)D level was analyzed. Receiver operating characteristic curve (ROC)was used to evalu-ate the predicting value of 25(OH)D in the elderly MCI patients. Results The serum 25(OH)D levels of the MCI group (n = 72)and NC group (n = 76)were (33. 43 ± 15. 04)nmol/ L and (41. 55 ± 17. 53)nmol/ L,respectively (P <0. 01). The 25(OH)D deficiency in the MCI group (n = 64,88. 9％)was different from the NC group (n = 51,67. 1％) (P < 0. 01). The serum 25(OH)D level and the MoCA score were positively correlated (r = 0. 219,P < 0. 01). The pa-tients with 25(OH)D deficiency had an increased risk of MCI (OR = 3. 816,P < 0. 01). Serum 25(OH)D had a value in predicting MCI in the elderly patients [AUC 0. 637,(95％ CI 0. 548-0. 727),P < 0. 01]. Serum 25(OH)D combined with education years and age had a more higher value in predicting MCI in the elderly patients [AUC 0. 723,(95％ CI 0. 642-0. 804),P < 0. 01]. Conclusions The serum 25(OH)D level of the elderly MCI patients is decreased. Serum 25(OH)D is related to MCI in the elderly patients. Serum 25(OH)D deficiency has an increased risk of MCI. Serum 25(OH)D may contribute to predicting MCI in the elderly patients.关键词
维生素D/25-羟维生素D/认知功能障碍/老年病Key words
vitamin D/25-hydroxyvitamin D/cognitive dysfunction/senile diseases分类
医药卫生引用本文复制引用
李娇娇,赵晨昭,邓利华,褚琳,陈陵霞,王晶桐..老年轻度认知功能障碍患者血清25-羟维生素D水平变化及其临床意义[J].山东医药,2017,57(43):5-7,3.基金项目
北京市科技计划项目(Z161100000116095). （Z161100000116095）
