山东医药2017，Vol.57Issue(43)：8-10,3.DOI:10.3969/j.issn.1002-266X.2017.43.003
新确诊的2型糖尿病、糖耐量减低患者认知功能和脑白质微结构的变化及相关性
Changes and correlation of cognitive function with microstructure of white matter in newly diagnosed type 2 diabetes mellitus and impaired glucose tolerance
摘要
Abstract
Objective To investigate whether there are cognitive dysfunction and white matter microstructure changes in patients with newly diagnosed type 2 diabetes mellitus (T2DM)and impaired glucose tolerance (IGT)and whether the two are related. Methods Twenty patients with newly diagnosed T2DM (T2DM group),18 newly diagnosed IGT patients (IGT group),and 17 normal subjects (normal group)received the Montreal Scale (MoCA)score and white matter mag-netic resonance diffusion tensor imaging (DTI)check [anisotropy (FA value)]. Then we analyzed the correlation between MoCA score and FA value. Results The MoCA scores of the T2DM group,IGT group,and normal group were 24. 78 ± 2. 42,26. 12 ± 1. 47,and 27. 16 ± 2. 21,respectively;the FA values of left white matter (FAl)in the T2DM group,IGT group,and normal group were 0. 4578 ± 0. 0201,0. 4723 ± 0. 0182,and 0. 4876 ± 0. 0200,respectively;the FA val-ues of right white matter (FAr)in the T2DM group,IGT group,and normal group were 0. 4698 ± 0. 0193,0. 4817 ± 0. 0368,and 0. 4927 ± 0. 0224,respectively;significant difference was found between every two groups (P < 0. 01),no significant difference was found between the IGT group and normal group (P > 0. 05),and significant difference was found between the T2DM group and IGT group,and between the T2DM group and the normal group (all P < 0. 05). There was a positive correlation between MoCA score and FAl in the T2DM group (r = 0. 432,P < 0. 05),but there was no correlation between MoCA score and FAr (r = 0. 605,P > 0. 05). Conclusion Newly diagnosed T2DM patients may have mild cog-nitive dysfunction and white matter microstructure changes,and the cognitive function and white matter microstructure in newly diagnosed IGT patients have not changed;newly diagnosed T2DM patients with left white matter changes in micro-structure may have a certain impact on cognitive decline.关键词
认知功能障碍/脑白质微结构/2型糖尿病并发症/2型糖尿病/糖耐量减低/蒙特利尔量表/磁共振弥散张量成像Key words
cognitive dysfunction/white matter microstructure/complications of type 2 diabetes/type 2 diabetes mellitus/impaired glucose tolerance/Montreal scale/magnetic resonance/diffusion tensor imaging分类
医药卫生引用本文复制引用
马一骏,李青菊,李俊,翟晨光,张园园..新确诊的2型糖尿病、糖耐量减低患者认知功能和脑白质微结构的变化及相关性[J].山东医药,2017,57(43):8-10,3.基金项目
河南省高等学校重点科研项目(17A320039). （17A320039）
