山东医药2017，Vol.57Issue(43)：11-13,3.DOI:10.3969/j.issn.1002-266X.2017.43.004
广西壮族自治区壮族人群MACROD2基因rs2208454位点单核苷酸多态性与缺血性脑卒中发病的关系
Relationship between rs2208454 single nucleotide polymorphism of MACROD2 gene and ischemic stroke in Zhuang population of Guangxi Zhuang autonomous region
摘要
Abstract
Objective To explore the relationship between single nucleotide polymorphism (SNP)of rs2208454 in MACROD2 gene and ischemic stroke (IS)in Zhuang population of Guangxi Zhuang autonomous region. Methods The rs2208454 single nucleotide of MACROD2 gene was detected by SNaPshot technique in 101 cases of Guangxi Zhuang IS pa-tients (IS group)and 104 healthy subjects (control group). Results The GG,GT,TT genotypes and G,T allele distri-bution of rs2208454 locus of MACROD2 gene were not statistically different between these two groups (all P > 0. 05). The rs2208454 locus SNP of MACROD2 gene was not associated with the risk of IS in dominant (TT + GT and GG),recessive (TT and GT + GG)and additive (TT and GG)genetic models (all P > 0. 05). Conclusion The rs2208454 locus SNP of MACROD2 gene has no correlation with the pathogenesis of IS in Guangxi Zhuang population.关键词
MACROD2基因/MACROD2基因rs2208454位点/单核苷酸多态性/脑卒中/缺血性脑卒中Key words
MACROD2 gene/MACROD2 gene rs2208454/single nucleotide polymorphism/stroke/ischemic stroke分类
医药卫生引用本文复制引用
江东东,罗曼..广西壮族自治区壮族人群MACROD2基因rs2208454位点单核苷酸多态性与缺血性脑卒中发病的关系[J].山东医药,2017,57(43):11-13,3.基金项目
广西壮族自治区自然科学基金资助项目(2013GXNSFBA019131,2015GXNSFAA139171). （2013GXNSFBA019131,2015GXNSFAA139171）
