山东医药2017，Vol.57Issue(43)：21-24,4.DOI:10.3969/j.issn.1002-266X.2017.43.007
胃癌组织中lncRNA-AK054978、lncRNA-FER1L4的表达观察
Expression of lncRNA-AK054978 and lncRNA-FER1L4 in patients with gastric cancer
摘要
Abstract
Objective To detect the expression levels of long non-coding RNA-AK054978 (lncRNA-AK054978)and lncRNA-FER1L4 in the tissues of gastric cancer and to explore its clinical significance. Methods Ninety-six cases of gas-tric cancer tissues and the adjacent tissues were obtained. The lncRNA-AK054978 and lncRNA-FER1L4 expression levels in the cancer tissues and the adjacent tissues were detected by the real-time quantitative PCR (qRT-PCR). The correla-tions of lncRNA-AK054978 / lncRNA-FER1L4 expression with the clinical characteristics were analyzed. The Kaplan-Meier method was used to detect the relationship between lncRNA-AK054978 / lncRNA-FER1L4 expression and gastric cancer pa-tients' survival. Results The relative expression levels of lncRNA-AK054978 in the gastric cancer tissues and the adjacent tissues were 7. 32 ± 2. 12 and 1. 04 ± 0. 12,respectively (P < 0. 05). The relative expression levels of lncRNA-FER1L4 in the gastric cancer tissues and the adjacent tissues were 0. 21 ± 0. 15 and 1. 09 ± 0. 22,respectively (P < 0. 05). In the gastric cancer tissues,the lncRNA-AK054978 / lncRNA-FER1L4 relative expression levels were correlated with the tumor diameter,differentiation grade,depth of invasion,lymph node metastasis status,distant metastasis status and TNM staging (all P < 0. 05). The Log Rank results showed that the 5-year overall survival rate and the mean survival time in the high-lncRNA-AK054978 group were 70. 83％ and (51. 94 ± 2. 29)months,which were much lower than 83. 33％ and (55. 06 ± 1. 81)months in the low-lncRNA-AK054978 group (both P < 0. 05);the 5-year overall survival rate and the mean sur-vival time in the low-lncRNA-FER1L4 group were 72. 92％ and (52. 23 ± 2. 24)months,which were much lower than 87. 50％ and (56. 38 ± 1. 64)in the high-lncRNA-FER1L4 group (P < 0. 01). Conclusions In the gastric cancer tis-sues,the lncRNA-AK054978 is highly expressed and the lncRNA-FER1L4 is lowly expressed. The high expression of ln-cRNA-AK054978 and the low expression of lncRNA-FER1L4 promote the development of gastric cancer. LncRNA-AK054978,FER1L4 may serve as biomarkers for the prognosis and the therapy of gastric cancer.关键词
长链非编码RNA/长链非编码RNA-AK054978/长链非编码RNA-FER1L4/胃癌Key words
long non-coding RNA/long non-coding RNA-AK054978/long non-coding RNA-FER1L4/gastric carci-noma分类
医药卫生引用本文复制引用
吕庆福,周好,过兆基,曹苇,支巧明..胃癌组织中lncRNA-AK054978、lncRNA-FER1L4的表达观察[J].山东医药,2017,57(43):21-24,4.基金项目
江苏省卫生和计划生育委员会医学科研计划项目(H201569). （H201569）
