世界中医药2017，Vol.12Issue(9)：2028-2031,4.DOI:10.3969/j.issn.1673-7202.2017.09.010
芪苈真武汤对慢性心功能不全患者心功能及血浆脑钠肽的影响
Effect of Qilizhenwu Decoction on Cardiac Function and Plasma Brain Natriuretic Eeptide in Patients with Chronic Heart Failure
摘要
Abstract
Objective:To investigate the effects of Qilizhenwu decoction on cardiac function and plasma brain natriuretic peptide (BNP) in patients with chronic heart failure.Methods:Using the prospective study method,112 patients with chronic heart failure who came to our hospital from August 2013 to January 2016 were randomized into an observation group and a control group,56 cases in each.The control group were treated with routine western medicine,the observation group extra Qilizhenwu decoction,both observed for 4 weeks.Results:After treatment,the total effective rates of the observation group and the control group were 96.4％ and 89.3％ respectively,observation group significantly higher than that of the control group (P ＜0.05).The LVEF values in the observation group and control group after treatment were (7.724 ± 5.22) ％ and (70.24 ± 4.56) ％,significantly higher than those before treatment,(60.24 ± 4.20) ％ and (60.11 ± 5.10) ％,(P ＜ 0.05),and the LVEF values in the observation group after treatment were significantly higher than those in control group (P ＜ 0.05).The plasma BNP values in the observation group and the control group after treatment were (1 673.42 ± 256.30) pg/mL and (1 655.09 ± 309.87) pg/mL,significantly lower than those before treatment,(180.24 ±45.10) pg/mL and (341.09 ±50.19) pg/mL,(P ＜0.05),and observation group was also significantly lower than those in the control group (P ＜ 0.05).The low shear and high shear viscosity of whole blood in the observation group after treatment were significantly lower than those before treatment (P ＜ 0.05),with significant group differences (P ＜ 0.05).Conclusion:Qilizhenwu decoction used in chronic heart function patients can effectively improve the cardiac function and hemodynamics and promote plasma BNP expression decreased to improve the overall treatment effect.关键词
芪苈真武汤/慢性心功能不全/心功能/脑钠肽/血流动力学Key words
Qilizhenwu decoction/Chronic heart failure/Cardiac function/Brain natriuretic peptide/Hemodynamics分类
医药卫生引用本文复制引用
仇军,张勇,郭宏杰..芪苈真武汤对慢性心功能不全患者心功能及血浆脑钠肽的影响[J].世界中医药,2017,12(9):2028-2031,4.基金项目
顺义区科技计划项目(201501) （201501）
