世界中医药2017，Vol.12Issue(9)：2065-2068,4.DOI:10.3969/j.issn.1673-7202.2017.09.020
柴胡桂枝汤联合西替利嗪治疗过敏性鼻炎的疗效及对炎性细胞因子的影响
Efficacy of Chaihu Guizhi Decoction Combined with Cetirizine in the Treatment of Allergic Rhinitis and Influence on Inflammatory Cytokines
摘要
Abstract
Objective:To explore the curative effect of Chaihu Guizhi Decoction combined with cetirizine in the treatment of allergic rhinitis and its influence on inflammatory cytokines.Methods:A total of 114 patients with allergic rhinitis who were admitted and treated in Jiangjin Central Hospital of Chongqing from March 2016 to January 2017 were selected and divided into the control group (n =57) and the treatment group (n =57) by random number table.The control group was treated with cetirizine,and the treatment group was treated with Chaihu Guizhi Decoction on the basis of the control group.Both groups were continually treated for 3 months.The clinical effects,the disappearance time of clinical symptoms,the signs and symptoms scores of 2 groups before and after treatment were compared,and the levels of inflammatory cytokines in 2 groups before and after treatment were detected and compared.Results:The total effective rate of the treatment group was 94.74％,which was significantly higher than that 82.46％ of the control group (P ＜ 0.05);The disappearance time of runny nose,nasal congestion,nasal itching and sneezing and other symptoms of the treatment group was earlier than those of the control group (P ＜ 0.05 or P ＜ 0.01);Scores of signs and symptoms in 2 groups after treatment were significantly lower when compared with that before treatment (P ＜0.01),and the treatment group were lower than the control group (P ＜ 0.05 or P ＜ 0.01);The levels of interferon-γ (IFN-γ),interleukin-10 (IL-10) of 2 groups after treatment significantly increased,and the levels of interleukin-4 (IL-4),interleukin-17 (IL-17) significandy decreased when compared that before treatment (P ＜ 0.05 or P ＜ 0.01),and the differences between the 2 groups were significant (P ＜ 0.01).Conclusion:Chaihu Guizhi Decoction combined with cetirizine can significantly improve the clinical symptoms and signs of the patients with allergic rhinitis,and reduce the inflammatory response with remarkable effects.关键词
过敏性鼻炎/柴胡桂枝汤/西替利嗪/炎性细胞因子/临床疗效Key words
Allergic rhinitis/Chaihu Guizhi Decoction/Cetirizine/Inflammatory cytokines/Clinical effects分类
医药卫生引用本文复制引用
张朝梅,陈雪梅..柴胡桂枝汤联合西替利嗪治疗过敏性鼻炎的疗效及对炎性细胞因子的影响[J].世界中医药,2017,12(9):2065-2068,4.基金项目
重庆市江津区科技项目(Y12012002) （Y12012002）
