世界中医药2017，Vol.12Issue(9)：2241-2245,5.DOI:10.3969/j.issn.1673-7202.2017.09.062
龙葵碱抗肿瘤作用及机制
Anti-cancer Effects and Mechanism of Glycoalkaloids from Solanum nigrum L
摘要
Abstract
Glycoalkaloids is one of the main constituents of Solanum nigrum L.,including solamargine,solasonine,and solanine.Glycoalkaloids was proved to have anti-cancer effects against lung cancer,breast cancer,liver cancer,pancreatic cancer,colorectal cancer,cervical cancer,prostate cancer,leukemia and other malignancies.Glycoalkaloids can inhibit cell proliferation,induce apoptosis and autophagy,block cell cycle,enhance effects of chemotherapy,inhibit epithelial-mesenchymal transition,metastasis and angiogenesis.These studies provide new basis for rational application and development of Glycoalkaloids.关键词
龙葵碱/中药药理学/抗肿瘤作用/机制Key words
Solanum Glycoalkaloids/Pharmacology of Chinese materiamedica/Anti-cancer effects/Mechanism分类
医药卫生引用本文复制引用
闫霞,郑佳露,胡兵..龙葵碱抗肿瘤作用及机制[J].世界中医药,2017,12(9):2241-2245,5.基金项目
国家自然科学基金(81273726,81473625) （81273726,81473625）
上海市中医药事业发展三年行动计划(ZY3-CCCX-3-3025) （ZY3-CCCX-3-3025）
上海市科技支撑项目(16401902500) （16401902500）
