生命科学研究2017，Vol.21Issue(5)：450-453,4.DOI:10.16605/j.cnki.1007-7847.2017.05.014
核糖体蛋白S26的研究进展
Research Progress of Ribosomal Protein S26
摘要
Abstract
Ribosomal proteins (RPs) not only participate in the synthesis of proteins in cells,but also have a variety of extraribosomal functions.The ribosomal protein S26 (RPS26) locates in the small subunit of ribosome,and its dysfunction is closely related to many diseases.Recent researches on RPS26 include the ribosomal functions such as participating in ribosome assembly,and extraribosomal functions such as participating in the nonsense-mediated mRNA decay (NMD),and directly or indirectly regulating the expression of the important tumor suppressor gene p53.Several reports confirmed that RPS26 gene mutations cause DiamondBlackfan anemia (DBA),and the relationship of RPS26 gene and type 1 diabetes (T1D) is still controversial.Exploring the role of RPS26 involved in NMD,which leads to DBA,helps to understand the pathogenesis of DBA,and also improve the efficiency of gene therapy with SMaRT (spliceosome-mediated RNA tram-splicing) method.In addition,the role of RPS26 in tumor formation is also worth exploring.关键词
核糖体蛋白S26 (RPS26)/无义介导的mRNA降解(NMD)/p53蛋白/戴-布二氏贫血(DBA)/Ⅰ型糖尿病(T1D)/癌症Key words
ribosomal protein S26 (RPS26)/nonsense-mediated mRNA decay (NMD)/p53/Diamond-Blackfan anemia (DBA)/type 1 diabetes (T1D)/cancer分类
生物科学引用本文复制引用
王枭宇,梁超,方肇勤..核糖体蛋白S26的研究进展[J].生命科学研究,2017,21(5):450-453,4.基金项目
国家自然科学基金资助项目(81473572,81273641) （81473572,81273641）
