实用肝脏病杂志2017，Vol.20Issue(6)：684-687,4.DOI:10.3969/j.issn.1672-5069.2017.06.012
替比夫定联合复方牛胎肝提取物治疗慢性乙型肝炎患者疗效及安全性评价
Clinical efficacy and safety of combination therapy of telbivudine and compound embryonic bovine liver extract in patients with chronic hepatitis B
摘要
Abstract
Objective To investigate the efficacy and safety of combined therapy of telbivudine and compound embryonic bovine liver extract in patients with chronic hepatitis B(CHB). Methods Eighty-seven patients with chronic hepatitis B were randomly divided into combination treatment group(n=43)and control group(n=44). Patients in combination treatment group were treated with compound embryonic bovine liver extract plus telbivudine,and those in control group were treated with telbivudine alone. The data of liver function index, renal function index,serum hyaluronic acid(HA),laminin(LN),type IV collagen(IV-C),type III procollagen,N-terminal peptide(P IIINP),creatine kinase(CK),HBV DNA undetectable rates,HBeAg loss rates and adverse reaction rates were compared between the two groups. Results At the end of 24 weeks of treatment,serum alanine transaminase(ALT),aspartate aminotransferase(AST)levels in combination treatment group were(25.4 ± 8.5)U/L,(23.8±6.5)U/L,respectively,significantly lower than those in control group [(46.3±9.3)U/L,(49.0±7.3) U/L,P<0.05];serum HA,LN,Ⅳ-C,PⅢNP levels in combination treatment group were(128.4±83.2)μg/L,(88.4± 64.3)μg/L,(64.4 ±49.0)μg/L,(112.3 ±73.8)μg/L,respectively,significantly lower than those in control group [(249.3 ±82.1)μg/L,(163.1 ±55.1)μg/L,(98.2 ±50.3)μg/L,(183.2 ±63.2)μg/L,P<0.01];serum HBV DNA undetectable,HBeAg loss and adverse reaction rates in the two groups were not significantly different(P>0.05). Conclusions Telbivudine combined with compound embryonic bovine liver extract can significantly improve the liver function and liver fibrosis in patients with CHB,and have a good safety profile.关键词
慢性乙型肝炎/替比夫定/复方牛胎肝提取物/治疗Key words
Chronic hepatitis B/Telbivudine/Compound embryonic bovine liver extract/Therapy引用本文复制引用
张宿荣,叶晓光,陈志伟..替比夫定联合复方牛胎肝提取物治疗慢性乙型肝炎患者疗效及安全性评价[J].实用肝脏病杂志,2017,20(6):684-687,4.基金项目
广州医科大学青年科研基金资助项目(编号:2015A04) （编号:2015A04）
