实用肝脏病杂志2017，Vol.20Issue(6)：688-691,4.DOI:10.3969/j.issn.1672-5069.2017.06.013
超声实时组织弹性成像定量分析对慢性乙型肝炎患者肝纤维化程度的诊断价值
Diagnostic value of quantitative analysis of liver fibrosis by real time tissue elastography in patients with hepatitis B
摘要
Abstract
Objective To analyze the diagnostic value of quantitative analysis of liver fibrosis by real time tissue elastography in patients with hepatitis B. Methods 175 patients with hepatitis B and 100 healthy persons between July 2015 and December 2016 were recruited in our hospital,and liver biopsies were performed in pa-tients with hepatitis B. Real-time tissue elastography(RTE)was conducted in the two groups. The receiver oper-ating characteristic curve(ROC)was used to analyze the efficacy of diagnostic value of each parameter. When the area under curve(AUC)of ROC was greater than 0.5,the diagnosis was set up. Results The average relative value(ARV)in health group was(128.3±8.1),much higher than(106.3±5.2)in CHB patients(P<0.05);the area ratio of low-strain region(AREA),complexity(COMP),skewness(SKEW),contrast(CONT)and inverse different moment(IDM)in health group were(3.7±0.5),(16.6±1.2),(-0.1±0.0),(91.8±9.1),(0.1±0.0),much lower than [(19.9±2.6),(29.4±3.1),(0.3±0.1),(173.9 ±17.9),(0.2 ±0.1),all P<0.05)in patients with CHB;the ARV in 67 patients with S0-S1 staging was(118.5±5.6),much higher than [(101.6±5.3),P<0.05] in 82 with S2-S3,and also much higher than [(89.7±4.9),P<0.05] in 26 with S4 staging;the AREA,COMP,SKEW,CONT and IDM in S0-S1 group were(9.4 ±1.7),(22.4 ±2.4),(0.11 ±0.0), (121.0±11.2),(0.1±0.0),much lower than [(23.5± 2.4),(31.8±2.7),(0.32 ±0.1),(188.2±15.2),(0.2 ± 0.1),all P<0.05)in S2-S3 group,and the AREA, COMP,SKEW,CONT in S2-S3 group were also much lower than [(36.2±2.6),(40.1±2.9),(0.46± 0.1),(265.3±16.1),all P<0.05)in S4 group;ROC curve analysis showed that the ARV,AREA and SKEW had diagnostic value for diagnosis of S0-S1,S2-S3 and S4 as the AUC were greater than 0.5. Conclusion Non invasive diagnosis of quantitative analysis by real time tissue elastography has diagnostic significance for liver fibrosis in patients with hepatitis B,and it might be used as one of the alternative methods for liver fibrosis.关键词
慢性乙型肝炎/超声实时组织弹性成像/肝纤维化/无创诊断Key words
Hepatitis B/Real time tissue elastography/Liver fibrosis/Non-invasive diagnosis引用本文复制引用
高秀芳,王一,刘玉珍,乐嘉芳..超声实时组织弹性成像定量分析对慢性乙型肝炎患者肝纤维化程度的诊断价值[J].实用肝脏病杂志,2017,20(6):688-691,4.基金项目
山东省卫生与计划生育委员会科研基金资助项目(编号:SW-2010B-027) （编号:SW-2010B-027）
