同位素2017，Vol.30Issue(4)：276-282,7.DOI:10.7538/tws.2017.youxian.035
PET/CT联合显像在雌激素与 阿尔茨海默病相关性研究中的价值
The Value of PET/CT Imaging in Alzheimer's Disease Patients with Different Levels of Estradiol
摘要
Abstract
The expressions of aplipoprotein E (ApoE) ,tumor necrosis factor-α(TNF-α) in Alzheimer's disease (AD) patients with different levels of estrogen were investigated to evaluate the diagnosis of combined PET/CT imaging (11 C-PIB and 18 F-FDG) on AD . A total of 75 female AD patients were divided into low level of estradiol group (E2 <16.2 pmol/L ,n=36) and normal level of estradiol group (16.2 pmol/L≤E2 <65.7 pmol/L , n=39) according to their estradiol levels .All the patients underwent PET/CT imaging (11 C-PIB and 18 F-FDG) .The sensitivity of PET/CT imaging ,the standard uptake value radio ,the expression rates of subtype ApoE (ε2 ,ε3 ,ε4) ,and the expression levels of TNF-α were detected .The relationship between E2 and the expression rates of ApoE , the levels of TNF-αand SUVR were analyzed by Pearson analysis .In the low level of E2 group ,the sensitivity of PET/CT for 11 C-PIB alone ,11 C-PIB combined with 18 F-FDG was higher than in normal E2 group (χ2 =4.869 , P=0.027 ;χ2 =3.636 , P=0.047);while the sensitivity of 18 F-FDG PET/CT imagings on brain between the two groups had no significant difference (χ2 = 2.007 , P= 0.157) .The expression level of E2 with SUVR and the expression level of TNF-αin two groups of AD patients had the negative correlations (r= -0.363 ,P=0.001 ;r= -0.248 ,P=0.032) .The expression rate of ApoEε4 allelic genes of AD patients was higher than that of ε2 andε3 allelic genes ,and there was higher expression rates of ApoE in AD patients with the low E2 group (Z=-2.228 ,P=0.026) .11C-PIB and 18 F-FDG PET/CT had high value of diagnosis in AD patients .关键词
阿尔茨海默病/雌二醇/载脂蛋白E/肿瘤坏死因子-αKey words
Alzheimer's disease/estradiol/apolipoprotein E/tumor necrosis factor-α分类
医药卫生引用本文复制引用
陆国秀,张国旭,郝珊瑚,郭佳,张文文,王治国,张景华..PET/CT联合显像在雌激素与 阿尔茨海默病相关性研究中的价值[J].同位素,2017,30(4):276-282,7.基金项目
2014年辽宁省自然科学基金资助项目(优秀人才培育专题)(20140220066) （优秀人才培育专题）
2017年辽宁省自然科学基金资助项目(20170540927) （20170540927）
