太原理工大学学报2017，Vol.48Issue(6)：1000-1006,7.DOI:10.16355/j.cnki.issn1007-9432tyut.2017.06.022
离子导入巩膜交联术对近视模型力学性能及胶原代谢的影响
The Effects of Iontophoresis-Assisted Cross-Linking on Biomechanical Properties and Collagen Metabolism of Myopic Rabbit Sclera
摘要
Abstract
Scleral collagen cross-linking (SXL)is one of the most promising treatments to control the pathologic process of myopia.The exact procedure and effects on myopic animal mod-els still need to be explored.We applied an iontophoresis-assisted delivery system to the ribofla-vin/ultraviolet A (UVA)SXL procedure,and conducted an accelerated UVA irradiation (10 mW/cm2 ,9 minutes)on a myopic animal model to explore the effects on scleral biomechanical properties and collagen metabolism.By form deprivation,ninety-six New Zealand white rabbits developed relatively stable myopia and then underwent the SXL surgery or sham-operation.All the sample and statistics were obtained from 4 time points (1-day,10-day,1-month and 3-month) after the surgery.The results show that the ultimate stress,Young's modulus and physiological Young's modulus of treated myopic sclera were significantly increased compared with those of un-treated ones in all four groups.In addition,there were significant differences in the expression of genes and proteins related to collagen metabolism between the treated sclera samples and untreat-ed ones.It demonstrated that iontophoresis-assisted accelerated Riboflavin/UVA SXL might be a potential method to control the pathological process of myopia.关键词
巩膜交联/近视模型/离子导入/生物力学性能/基因及蛋白表达/核黄素-紫外线AKey words
scleral cross-linking/myopic model/iontophoresis/biomechanical properties/gene and protein expressions/riboflavin/ultraviolet A分类
医药卫生引用本文复制引用
容烁,王超英,韩宝雁,冯鹏飞,兰伟伟,李晓娜,陈维毅..离子导入巩膜交联术对近视模型力学性能及胶原代谢的影响[J].太原理工大学学报,2017,48(6):1000-1006,7.基金项目
国家自然科学基金资助项目(31271005,11402162) （31271005,11402162）
