中国组织工程研究2017，Vol.21Issue(31)：5078-5084,7.DOI:10.3969/j.issn.2095-4344.2017.31.027
降钙素原诊断成人骨关节感染的Meta分析
Diagnostic value of procalcitonin for articular infection in adults: a meta-analysis
摘要
Abstract
BACKGROUND: Due to special physiological characteristics, articular infection is difficult to be cured successfully. Early diagnosis is critical for the treatment of articular infection, thereafter, searching for a biomarker with high sensitivity and specificity is necessary.OBJECTIVE: To systematically evaluate the value of procalcitonin for diagnosing joint infection in adult.METHODS: A computer-based online research was performed for the literature in PubMed, EMbase, the Cochrane Library and CNKI databases from 1990 to June 2017. Literature screening and data extraction were conducted by two reviewers independently according to the inclusion and exclusion criteria. The risk of bias of included studies was assessed by using the Quality Assessment of Diagnostic Accuracy Studies-2. Meta-analysis was then performed using Stata 14.0 software. The pooled weighted sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio were calculated; the summary receiver operating characteristic curve was drawn and the area under the curve was calculated.RESULTS AND CONCLUSION: (1) A total of 10 studies were included, involving 893 patients. (2) The pooled weighted sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio of procalcitonin diagnosing joint infection were 0.82 (95%CI=0.72-0.89), 0.89 (95%CI=0.82-0.93), 7.20 (95%CI=4.6-11.3), 0.20 (95%CI=0.13-0.32), 35 (95%CI=18-71) and 0.92 (95%CI=0.90-0.94), respectively. (3) To conclude, procalcitonin exhibits more diagnostic efficiency for assessing articular infection in adults.关键词
骨科植入物/骨植入物/骨关节炎/骨髓炎/关节炎,感染性/降钙素原/诊断试验/Meta分析/国家自然科学基金分类
医药卫生引用本文复制引用
王婷婷,孙伟鹏,梁爽,张贵育,周驰,朱美玲..降钙素原诊断成人骨关节感染的Meta分析[J].中国组织工程研究,2017,21(31):5078-5084,7.基金项目
国家自然科学基金(81373655) （81373655）
广东省自然科学基金(2015A030310203) （2015A030310203）
深圳市科技创新委员会基金(JCYJ20150401161033959)the National Natural Science Foundation of China, No. 81373655 （JCYJ20150401161033959）
the Natural Science Foundation of Guangdong Province, No. 2015A030310203 （）
the Foundation of Shenzhen Science and Technology Innovation Commission, No. JCYJ20150401161033959 （）
