中国组织工程研究2017，Vol.21Issue(32)：5091-5096,6.DOI:10.3969/j.issn.2095-4344.2017.32.002
绝经后妇女血清激素受体共激活因子3与骨密度、骨转换水平的相关性
Implication of serum steroid receptor coactivator-3 level for lumbar bone mineral density and bone turnover in postmenopausal women
摘要
Abstract
BACKGROUND: Steroid receptor coactivator-3 (SRC-3) is a member of the steroid receptor coactivator family,and it can promote proliferation and differentiation in human osteoblasts by modulating estrogen receptor activity. Previous studies have reported that allelic variation at the SRC-3 locus is significantly positively correlated with the lumbar bone mineral density in Caucasian men, but the relationship between SRC-3 and bone metabolism in postmenopausal women remains unknown.OBJECTIVE: To investigate the level of serum SRC-3 in postmenopausal women and its association with bone mineral density and bone turnover markers.METHODS: Fifty-five women with postmenopausal osteoporosis and 35 healthy postmenopausal women were recruited, and their serum levels of SRC-3, 25-hydroxyvitamin D, osteocalcin and procollagen I N-terminal peptide, beta C-terminal telopeptide of type I collagen were detected. The bone mineral density of L1-4 vertebrae and femoral neck were measured by dual-energy X-ray absorptiometry.RESULTS AND CONCLUSION: Serum SRC-3 level in postmenopausal women with osteoporosis was remarkably lower than that in healthy individuals. In addition, the serum SRC-3 level was positively correlated with lumbar bone mineral density, and negatively correlated with procollagen I N-terminal peptide and osteocalcin in postmenopausal women with osteoporosis. These results indicate that low serum SRC-3 level may be involved in the pathogenesis of postmenopausal osteoporosis and play a pivotal role in bone turnover.关键词
组织构建/骨组织工程/激素受体共激活因子3/绝经后妇女/骨密度/骨代谢/骨转换标记物/骨质疏松症/国家自然科学基金分类
医药卫生引用本文复制引用
展磊,魏秋实..绝经后妇女血清激素受体共激活因子3与骨密度、骨转换水平的相关性[J].中国组织工程研究,2017,21(32):5091-5096,6.基金项目
国家自然科学基金项目(81302994,81473697) （81302994,81473697）
the National Natural Science Foundation of China,No. 81302994 and 81473697 （）
