疑难病杂志2017，Vol.16Issue(11)：1101-1103,1108,4.DOI:10.3969/j.issn.1671-6450.2017.11.006
糖尿病患者肺功能变化及与氧化应激反应的相关性
Change of lung function in patients with diabetes and its correlation with oxidative stress
倪红燕 1顾慧玲 1王海峰 1杨文林 1王丽华 1张旭峰 2郭绍文2
作者信息
- 1. 200940 上海市第一人民医院宝山分院呼吸科
- 2. 200021 上海中医药大学附属曙光医院病理科
- 折叠
摘要
Abstract
Objective To explore the change of lung function in patients withtype 2 diabetes mellitus (T2DM),and analyze its correlation with oxidative stress.Methods Eighty patients (T2DM group) with T2DM who were admitted in our hospital from 2014 Jan to 2016 Dec were retrospectively analyzed.According to blood sugar levels,whether merger complications,T2DM group was further divided into mild (n =32),moderate (n =27) and severe (n =21),with complications (n =42),without complications (n =38).The indicators of lung function and oxidative stress were detected,and the correlation between them was analyzed.Results Compared with control group,the levels of FVC,FEV1,FEV1/FVC in T2DM group were significantly reduced,MDA content was increased significantly,activity of GSH-PX and SOD were reduced (P ＜ 0.05);With the increase of disease severity,lung function in T2DM group was decreased significantly,MDA content was increased significantly,activity of GSH-PX and SOD were reduced (P ＜ 0.05).Compared with that without complications,the levels of FVC,FEV1,FEV1/FVC in T2DM group with complications were significantly reduced,MDA content was increased significantly,activity of GSH-PX and SOD were reduced (P ＜ 0.05);FEV1,FEV1/FVC in T2DM patients was significantly associated with all the indicators of oxidative stress,FVC and GSH-PX was significandy positively correlated (P ＜ 0.05).Conclusion T2DM lung impairment is an chronic complication of T2DM,and associated with disease severity,oxidative stress may be involved in process of lung impairment.关键词
2型糖尿病/肺功能/氧化应激反应/相关Key words
Type 2 diabetes mellitus/Lung function/Oxidative stress/Correlation引用本文复制引用
倪红燕,顾慧玲,王海峰,杨文林,王丽华,张旭峰,郭绍文..糖尿病患者肺功能变化及与氧化应激反应的相关性[J].疑难病杂志,2017,16(11):1101-1103,1108,4.
