疑难病杂志2017，Vol.16Issue(11)：1141-1144,4.DOI:10.3969/j.issn.1671-6450.2017.11.016
胺碘酮联合美托洛尔治疗快速心律失常疗效和安全性的Meta分析
Efficacy and safety of amiodarone and metoprolol for treating tachyarrhythmia: a Meta-analysis
摘要
Abstract
Objective To evaluate the efficacy and safety of amiodarone combined with metoprolol in the treatment of tachyarrhythmia.Methods Collecting the randomized controlled trials (RCT) about metoprolol and amiodarone alone on the treatment of tachyarrhythmia.The quality evaluation was performed using the scale developed by the Jadad improvement method.The extracted data was analyzed by RevMan 5.3 software.Results The results were included 9 papers according to the standard.The results of meta-analysis showed that the total effective rate of amiodarone combined with metoprolol in the treatment of tachyarrhythmia was higher than that of amiodarone alone (OR =7.98,95％ CI 4.64 to 13.70,P ＜ 0.01);the heart rate was lower than that of amiodarone alone (SMD =-22.01,95％ CI-27.20 to-16.81,P ＜0.01) and systolic blood pressure after treatment was lower than that of amiodarone alone (SMD =-24.23,95％ CI-26.04 to-22.43,P ＜ 0.01).Mter treatment,the diastolic blood pressure was lower than that of amiodarone alone group (SMD =-13.62,95％ CI-15.25 to-12.00,P ＜ 0.01).There was no significant difference in the overall incidence of adverse reactions after treatment (OR =0.83,95％ CI 0.44 to 1.59,P =0.58).Conclusion Amiodarone combined with metoprolol group can improve the total effective rate of rapid arthythmia treatment.After treatment,heart rate,systolic blood pressure and diastolic blood pressure are lower than amiodarone alone group,and it will not increase its toxic and side effects.关键词
胺碘酮/美托洛尔/快速心律失常/荟萃分析/随机对照试验Key words
Amiodarone/Metoprolol/Tachyarrhythmia/Meta-analysis/Randomized controlled trial引用本文复制引用
张文艳,胡钢英,陈素琴..胺碘酮联合美托洛尔治疗快速心律失常疗效和安全性的Meta分析[J].疑难病杂志,2017,16(11):1141-1144,4.基金项目
湖北省自然科学基金资助项目(2013CFB250) （2013CFB250）
