应用化学2017，Vol.34Issue(11)：1279-1286,8.DOI:10.11944/j.issn.1000-0518.2017.11.160502
吡唑并[4′,3′:5,6]吡喃并[2,3-d]嘧啶化合物的合成与生物活性
Synthesis and Biological Activity of Pyrazolo[4′,3′:5,6]pyrano[2,3-d]pyrimidine Derivatives
摘要
Abstract
A series of new 2-substituted-3 ,8-diphenyl-5-aryl-6-methyl-5 ,8-dihydropyrazolo [4′,3′:5 ,6 ] pyrano[2,3-d ]pyrimidine derivatives was designed and synthesized via tandem aza-Wittig reaction. The structures of target compounds were confirmed by 1 H NMR,IR spectra and elemental analysis. The structure of 2-dipropylamino-3,8-diphenyl-5-(4-methylphenyl)-6-methyl-5,8-dihydropyrazolo[4′,3′:5,6]pyrano[2,3-d]pyrimidin-4(3H)-one was determined by single crystal X-ray diffraction. The results of preliminary bioassay indicate that some compounds possess good inhibition activities against Botrytis cinereapers at a dosage of 5. 0 × 10 -5 g/mL,and the inhibition rates against Botrytis cinereapers are above 90%. Target compounds possess no insecticidal activity against Nilaparvatalegen, but show obvious insecticidal activity against Mythimaseparata,and the inhibihition rates against Mythimaseparata are above 60%.关键词
氮杂Wittig反应/吡唑并嘧啶/吡喃并嘧啶/生物活性Key words
Aza-Wittig reaction/pyrazolopyrimidine/pyranopyrimidine/biological activity分类
化学化工引用本文复制引用
刘建超,任青云,贺红武..吡唑并[4′,3′:5,6]吡喃并[2,3-d]嘧啶化合物的合成与生物活性[J].应用化学,2017,34(11):1279-1286,8.基金项目
国家自然科学基金(21172090,31000867)、教育部创新团队(IRT0953)资助 （21172090,31000867）
Supported by the National Natural Science Fundation of China(No. 21172090,No. 31000867),the Program for Changjiang Scholars and Innovatives Research Team in University(No. IRT0953) （No. 21172090,No. 31000867）
