应用化学2017，Vol.34Issue(11)：1295-1300,6.DOI:10.11944/j.issn.1000-0518.2017.11.170005
氯化胆碱催化合成香豆素-3-羧酸
Choline Chloride Promoted Synthesis of Coumarin-3-carboxylic Acids
摘要
Abstract
The synthesis of coumarin-3-carboxylic acids in a more convenient way has attracted considerable attention from organic and medicinal chemists. In this paper,a simple and effective method was described through a Knoevenagel-intramolecular cyclization tandem reaction of 2-hydroxyarylaldehydes with Meldrum′s acid at room temperature. Employing commercially available,mild,and nontoxic choline chloride as the accelerant and using the mixture of water and ethanol as solvent is highly applicable to get a satisfactory outcome from 88% to 96%. This approach expands the method for the preparation of coumarin-3-carboxylic acids and also provides other advantages such as mild reaction conditions,tolerant the substrates with diverse functional groups,and simple post-treatment process.关键词
香豆素-羧酸/氯化胆碱/水相/室温/绿色合成Key words
coumarin-carboxylic acids/choline chloride/water/room temperature/green synthesis分类
化学化工引用本文复制引用
肖迪,郑旺,魏晓玉,郎健,高爽秋,吕成伟..氯化胆碱催化合成香豆素-3-羧酸[J].应用化学,2017,34(11):1295-1300,6.基金项目
国家自然科学基金(21403100)和辽宁省博士启动基金(20141100)资助项目 （21403100）
Supported by the National Natural Science Foundation of China (No. 21403100 ),the Doctoral Scientific Research Foundation of Liaoning Province(No. 20141100) （No. 21403100 ）
