中国康复理论与实践2017，Vol.23Issue(11)：1313-1316,4.DOI:10.3969/j.issn.1006-9771.2017.11.015
自噬相关基因Atg7 rs11706903单核苷酸多态性与帕金森病的相关性
Association of Single Nucleotide Polymorphisms of Autophagy-related Genes Atg7 Site rs11706903 and Parkin-son's Disease
摘要
Abstract
Objective To investigate the relationship between the single nucleotide polymorphisms(SNP)of rs11706903,intron region of Atg7,and Parkinson's disease(PD).Methods From January,2013 to March,2017,130 PD patients and 109 healthy subjects were recruit-ed and collected the blood samples.SNPs of rs11706903 were detected with polymerase chain reaction restriction fragment length polymor-phism.Results For the patients,the genotype frequencies of rs11706903 were AA 10.00%,AC 52.31% and CC 37.69%;and allele frequen-cies were A 36.15% and C 63.85%.For the healthy controls,the genotype frequencies of rs11706903 were AA 7.34%,AC 49.54% and CC 43.12%;and allele frequencies were A 32.11% and C 67.89%.There was no significant difference in frequencies of genetypes and alleles be-teen two groups(χ 2<1.001,P>0.05).Conclusion There might be no relationship between SNPs of Atg7 intron region rs11706903 and PD.关键词
帕金森病/自噬相关基因/内含子/单核苷酸多态性/rs11706903Key words
Parkinson's disease/autophagy-related genes/intron/single nucleotide polymorphisms/rs11706903分类
医药卫生引用本文复制引用
贺鹏,赵西耀,陈煜森,陈霄仪,郑伟明..自噬相关基因Atg7 rs11706903单核苷酸多态性与帕金森病的相关性[J].中国康复理论与实践,2017,23(11):1313-1316,4.基金项目
杭州市医疗卫生科研项目(No.20150633B82). （No.20150633B82）
