中国免疫学杂志2017，Vol.33Issue(11)：1713-1715,3.DOI:10.3969/j.issn.1000-484X.2017.11.024
血清肥大细胞羧肽酶与支气管哮喘的相关性研究
Research on relationship between serum mast cell carboxypetidase levels and bronchial asthma
郭强 1唐颖 1闫百灵 1刘芝 2斯琴 1许力军1
作者信息
- 1. 吉林大学第一医院,长春130021
- 2. 内蒙古民族大学附属医院,通辽028007
- 折叠
摘要
Abstract
Objective:To investigate the role of the mast cell carboxypetidase in the pathogenesis of bronchial asthma through measuring the serum.The mast cell carboxypetidase levels of asthma patients,and further study the relationship between the mast cell carboxypetidase levels and pulmonary function or IgE.Methods: There were person with Moderate and severe persistent asthma were recruited into this study as the case group.The experience of the pulmonary function and immunoglobulin E levels have been complicat-ed.The person were divided into IgE increased group(n=20) and IgE normal group (n=15) according to the IgE level.And there were healthy person were recruited as the matched group.The mast cell carboxypetidase were measured using ELISA.The level of mast cell carboxypetidase were compared among asthma patients and healthy patients.The correlation between the mast cell carboxypetidase and IgE or the lung function.Results:The level of plasma mast cell carboxypetidase in the person with asthma was higher than that in healthy control group(P<0.05).The level of plasma mast cell carboxypetidase of the person in IgE increased group was higher than that in IgE normal group(P<0.05).In addition,there was a significant negative correlation between the serum mast cell carboxypetidase levels and FEV1(%) in the asthma acute phase,but there was no correlation in the stability of asthma(r=-0.42,P=0.044;r=-0.284,P=0.099).Conclusion: The mast cell carboxypetidase leve,as an inflammatory factor,could participates in the airway in-flammatory response of the asthma acute phase.关键词
支气管哮喘/肥大细胞羧肽酶/免疫球蛋白E/肺功能Key words
Bronchial asthma/Mast cell carboxypetidase/IgE/Lung function分类
医药卫生引用本文复制引用
郭强,唐颖,闫百灵,刘芝,斯琴,许力军..血清肥大细胞羧肽酶与支气管哮喘的相关性研究[J].中国免疫学杂志,2017,33(11):1713-1715,3.
