中国内镜杂志2017，Vol.23Issue(11)：101-105,5.DOI:10.3969/j.issn.1007-1989.2017.11.021
显微镜结肠炎临床特征及其相关危险因素分析
Clinical features and risk factors in patients with microscopic colitis
吴蓉 1李国熊 1杨文君 1李丽 1陈晶 1周刚 1方家恒1
作者信息
- 1. 杭州师范大学附属医院 消化内科,浙江 杭州 310015
- 折叠
摘要
Abstract
Objective To analyze the clinical, endoscopic and pathological data of patients with chronic diarrhea, and explore the possible risk factors of microscopic colitis (MC). Methods A prospective analysis of the clinical data of patients with complaints of watery diarrhea from June 2016 to April 2017 was conducted. All patients received colonoscopy examination with multi-point intestinal mucosal biopsy, histopathological and HE Masson staining. The history and pathology were analyzed. Results In 102 cases of watery diarrhea, MC was diagnosed in 3 cases (3/102, 2.94％), of which there were 3 cases of collagenous colitis (CC) in all these cases, all of them were female, aged 24～36 years old, and no lymphocytic colitis (LC) in all these cases. Mucous membrane of normal or mild hyperemia and edema showed only; histopathology showed epithelial cell injury, intraepithelial lymphocytosis, inflammatory cell infiltration in lamina propria, subepithelial collagen thickening. Recent hypoglycemic agents, PPIs, gluten and other factors may be closely related to the incidence of MC. Conclusion MC is an important cause of chronic diarrhea, the clinical symptoms and endoscopic manifestations are nonspecific, chronic diarrhea patients should undergo colonoscopy under multi-point biopsy, the incidence may be related to the use of certain drugs (such as hypoglycemic agents, PPIs) and some foods (gluten).关键词
显微镜结肠炎/淋巴细胞性结肠炎/胶原性结肠炎/面筋Key words
microscopic colitis/lymphocytic colitis/collagenous colitis/gluten分类
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吴蓉,李国熊,杨文君,李丽,陈晶,周刚,方家恒..显微镜结肠炎临床特征及其相关危险因素分析[J].中国内镜杂志,2017,23(11):101-105,5.
