中国人兽共患病学报2017，Vol.33Issue(10)：877-881,5.DOI:10.3969/j.issn.1002-2694.2017.10.005
鸭坦布苏病毒甲基转移酶的序列分析和结构预测
Sequence analysis and structure prediction of the methyltransferase of duck Tembusu virus
摘要
Abstract
In order to determine the amino acid sequence of functionthat play a role of methyltransferase (MTase) activity in duck Tembusu virus (DTMUV),we have made sequence analysis and structure prediction of the MTase in DTMUV by bioin formatics methods,as well as using the sequence and structure of MTase in other flaviviruses which have been reported.The bioinformatical analysis results showed that the MTase and the MTase of other three kinds of flaviviruses had the higher homology in nucleotide sequence and amino acid sequence,for 64.76％,64.55％,67.33％ and 74.71％,68.45％,75.15％ respectively,and the same basic structural characteristics which contained SAM binding site and had a typical of 4 alpha screw and 7 beta folding.At the same time,there were classical conservative sites K-D-K-E of flavivirus MTase in DTMUV MTase sequence.In conclusion,they imply that the MTase of DTMUV might belong to MTase family of flaviviruses.关键词
鸭坦布苏病毒/甲基转移酶/序列分析/结构预测Key words
duck Tembusu virus/methyltransferase/sequence analysis/structure prediction引用本文复制引用
武学东,张悦天,贾仁勇..鸭坦布苏病毒甲基转移酶的序列分析和结构预测[J].中国人兽共患病学报,2017,33(10):877-881,5.基金项目
Funded by the Application and Base Research Project of Sichuan Science and Technology Department (No.2017JY0014).四川省科技厅应用基础研究项目资助(No.2017JY0014) （No.2017JY0014）
