中国现代医学杂志2017，Vol.27Issue(27)：71-76,6.DOI:10.3969/j.issn.1005-8982.2017.27.013
代谢综合征与老年缺血性脑卒中继发血管性认知功能障碍的相关性分析
Relationship between metabolic syndrome and vascular cognitive impairment in elderly patients after ischemic stroke
摘要
Abstract
Objective To explore the relationship between metabolic syndrome (MS) and vascular cognitive impairment (VCI) after ischemic stroke. Methods A total of 225 elderly ischemic stroke patients were selected from January 2015 to December 2016 in this retrospective study. All the patients were divided into study group (67 cases with MS) and control group (158 cases without MS). Admission blood lipids, blood pressure, blood glucose and β-amyloid protein of the two groups were collected, and the incidence of diabetes, hypertension, hyperlipidemia were compared between the two groups. Montreal cognitive function score (MoCA) was used to evaluate cognitive function to calculate the incidence of VCI before discharge. Logistic regression analysis was used to explore the independent influencing factors of VCI. Results There were significant differences in β-AP, HOMA-IR, HbAlc, LDL-C, HDL-C, BP and other indicators between the two groups in admission ( < 0.05). Study group presented significantly higher incidence on T2DM, hypertension, hyperlipidemia and multiple lesions than those in the control group ( <0.05). The total MoCA score of the patients in the study group was significantly lower than that in the control group before discharge ( <0.05), and VCI incidence rate in the study group was significantly higher than that in the control group ( <0.05).Age, neural function defect score, multiple lesions, number of MS components were independent risk factors of VCI secondary to ischemic stroke ( <0.05), and the more the number of MS syndromes was and the higher of the age and neurological deficit score were, the higher the incidence of risk of VCI was ( (OR) > 1). Conclusions The cognitive impairment secondary to ischemic stroke is more serious in patients with MS than without MS, and MS can be an independent predictor of VCI after ischemic stroke.关键词
代谢综合征/血管性认知功能障碍/生化标志物/糖尿病/蒙特利尔认知功能评分/危险因素Key words
metabolic syndrome/vascular cognitive impairment/biochemical markers/diabetes mellitus/montreal cognitive function score/risk factors分类
医药卫生引用本文复制引用
董芳,杜怡峰..代谢综合征与老年缺血性脑卒中继发血管性认知功能障碍的相关性分析[J].中国现代医学杂志,2017,27(27):71-76,6.基金项目
山东省医药卫生科技发展计划(No:2016W0421) （No:2016W0421）
