中国现代医学杂志2017，Vol.27Issue(27)：91-95,5.DOI:10.3969/j.issn.1005-8982.2017.27.017
14例血栓性血小板减少性紫癜临床研究
Clinical study on thrombotic thrombocytopenic purpura in14 cases
陈建军 1肖佩玲 1李芳 1谭熹 1刘灿 1周明1
作者信息
- 1. 湖南省人民医院(湖南师范大学第一附属医院)血液科,湖南 长沙 410005
- 折叠
摘要
Abstract
Objective To investigate the clinical features and treatment of patients with thrombotic thrombocytopenic purpura (TTP) to improve the diagnosis and treatment level. Methods Retrospective study of 14 cases with TTP was conducted in general conditions clinical features, laboratory tests, treatment protocols, therapeutic effect and prognosis. Results Of the 14 patients, 13 had neurological symptoms, 4 had quinary syndrome, 9 had triad syndrome, 2 were recurrent and 6 were dead. The levels of platelet (PLT), hemoglobin (Hb) and lactate dehydrogenase (LDH) were significantly different between before and after plasma exchange (PE) ( <0.05). Two patients were treated with Rituximab and its remission rate was 100% (2/2). Conclusions Most of patients with TTP often have triad syndrome onset and accompany by neurological symptoms, and plasma exchange is the most effective treatment. For recurrent ones, Rituximab can improve the remission rate.关键词
血栓性血小板减少性紫癜/血浆置换/利妥昔单抗/临床诊疗Key words
thrombotic thrombocytopenic purpura/plasma exchange/Rituximab/clinical treatment分类
医药卫生引用本文复制引用
陈建军,肖佩玲,李芳,谭熹,刘灿,周明..14例血栓性血小板减少性紫癜临床研究[J].中国现代医学杂志,2017,27(27):91-95,5.
