中国现代医学杂志2017，Vol.27Issue(27)：96-99,4.DOI:10.3969/j.issn.1005-8982.2017.27.018
肝硬化食管胃底静脉曲张破裂出血患者预防性应用抗生素的疗效分析
Efficacy of prophylactic antibiotics in cirrhosis patients with gastroesophageal variceal bleeding
摘要
Abstract
Objective To explore the effect of early prophylactic antibiotics in cirrhosis patients with gastroesophageal variceal bleeding. Methods A total of 120 cirrhosis patients with gastroesophageal variceal bleeding were randomly assigned to antibiotic prophylaxis group ( =60) and control group ( =60), and all of them were provided with routine treatment including inhibition of acid, hemostasis, reduction of portal pressure and blood transfusion. Patients were received intravenous infusion of Cefotaxime Sodium (2.0 g, Bid, 7 days) in the antibiotic prophylaxis group. The incidence of re-bleeding, mortality and nosocomial infections were analysed between the two groups. Results There were statistical differences ( <0.05) between the antibiotic prophylaxis group and the control group in the incidence of rebleeding (8.90%/23.1%), mortality (5.4%/17.3%) and the incidence of nosocomial infections (17.9%/53.8%). Conclusions Prophylactic antibiotics can decrease incidence of re-bleeding, mortality and nosocomial infections of cirrhosis patients with gastroesophageal variceal bleeding to improve their quality of life.关键词
肝硬化/抗生素/食管胃底静脉曲张Key words
liver cirrhosis/antibiotics/gastrointestinal hemorrhage分类
医药卫生引用本文复制引用
郑娟红,贾杰,余炳取,陈佳园..肝硬化食管胃底静脉曲张破裂出血患者预防性应用抗生素的疗效分析[J].中国现代医学杂志,2017,27(27):96-99,4.基金项目
温州市科学技术局基金项目(No:2015Y0371) （No:2015Y0371）
