中国医科大学学报2017，Vol.46Issue(7)：591-594,4.DOI:10.12007/j.issn.0258-4646.2017.07.004
白藜芦醇对链脲霉素诱导的糖尿病大鼠神经病理性疼痛的作用
Effects of Resveratrol on Streptozotocin-induced Diabetic Neuropathic Pain in Rats
摘要
Abstract
Objective To investigate the effects of resveratrol on diabetic neuropathic pain induced by streptozotocin (STZ) in rats.Methods The subjects were pretreated with resveratrol (40 mg/kg) intraperitoneally,30 min before an intraperitoneal injection of STZ (60 mg/kg).Mechanical and cold allodynia were tested before and 1 to 4 weeks after the drug administration.Thermal hyperalgesia was also investigated.In addition,the transient receptor potential (TRP) Ankyrin 1 (TRPA1) and TRP melastatin 8 (TRPM8) expression levels in the dorsal root ganglia (DRG) were evaluated.Results Pretreatment with resveratrol significantly inhibited STZ-induced mechanical and cold allodynia,but not thermal hyperalgesia.The STZ injection increased TRPM8 expression levels (P ＜ 0.05),but not TRPA1 (P＞ 0.05) expression levels,in the DRG.Pretreatment with resveratrol decreased STZ-induced TRPM8 expression levels in the DRG (P ＜ 0.05).Conclusion The results demonstrated that pretreatment with resveratrol had strong anti-allodynic effects in STZ-induced diabetic tats,which might be associated with TRPM8 located in the DRG.关键词
白藜芦醇/链脲霉素/糖尿病/大鼠/神经病理性疼痛Key words
resveratrol/streptozotocin/diabetics/rat/neuropathic pain分类
医药卫生引用本文复制引用
刘晓颖,姚俊洁,刘文..白藜芦醇对链脲霉素诱导的糖尿病大鼠神经病理性疼痛的作用[J].中国医科大学学报,2017,46(7):591-594,4.基金项目
国家自然科学基金(81300671) （81300671）
