中国医科大学学报2017，Vol.46Issue(7)：600-603,608,5.DOI:10.12007/j.issn.0258-4646.2017.07.006
高同型半胱氨酸血症对慢性稳定性冠状动脉粥样硬化性心脏病患者肾功能的影响
Hyperhomocysteinemia Promotes Renal Function Impairment in Patients with Chronic Stable Coronary Artery Disease
摘要
Abstract
Objective To investigate the possible mechanism of hyperhomocysteinemia (HHcy) in renal dysfunction in patients with chronic stable coronary artery disease (SCAD).Methods We consequentially enrolled patients diagnosed as having SCAD and,according to homocysteine (Hcy) levels,divided them into the HHcy group (Hcy≥15 μmol/L,n =53) and control group (Hcy＜15 μmol/L,n =47).We further tested the relationship among plasma Hcy level,renal function,and serum levels of interleukin (IL)-6 and adiponectin (APN).Results IL-6 was significantly higher in the HHcy group than in the control group (P ＜ 0.05).However,APN level was obviously lower in the HHcy group than in the control group (P ＜ 0.05).Correlation analysis revealed that Hcy level positively correlated with creatinine (r =0.379,P ＜ 0.001),uric acid (r =0.238,P =0.019),cystatin C (r =0513,P ＜ 0.001),and IL-6 levels (r =0.561,P ＜ 0.001) but negatively correlated with estimated glomerular filtration rate (eGFR;r =-0.288,P =0.023) and APN level (r =-0.428,P ＜ 0.001).IL-6 level showed positive correlations with creatinine (r =0.406,P =0.002),uric acid (r =0.359,P =0.007),and cystatin C levels (r =0.387,P =0.007) but a negative correlation with eGFR (r =-0.370,P =0.005).Meanwhile,APN level showed negative correlations with creatinine (r =-0.694,P ＜ 0.001),uric acid (r =-0.420,P ＜0.001),and cystatin C levels (r =-0.553,P ＜ 0.001),but a positive correlation with eGFR (r =0.251,P =0.034).Conclusion Plasma Hcy level may have a predictive value for renal dysfunction in patients with SCAD.Moreover,HHcy probably promoted renal dysfunction by inducing the imbalance of anti-inflammation and pro-inflammation in patients with SCAD.关键词
高同型半胱氨酸血症/炎症状态/肾功能不全/慢性稳定性冠状动脉粥样硬化性心脏病Key words
hyperhomocysteinemia/inflammation/renal dysfunction/chronic stable artery disease分类
医药卫生引用本文复制引用
苏艳红,郑红梅,郭旭,王晓鸥,张新忠,张大庆..高同型半胱氨酸血症对慢性稳定性冠状动脉粥样硬化性心脏病患者肾功能的影响[J].中国医科大学学报,2017,46(7):600-603,608,5.基金项目
国家自然科学基金(81200199) （81200199）
