中国医科大学学报2017，Vol.46Issue(7)：628-631,4.DOI:10.12007/j.issn.0258-4646.2017.07.012
骨膜蛋白在乳腺癌中的表达及临床意义
Expression and Clinical Significance of Periostin in Breast Cancer
摘要
Abstract
Objective To investigate the expression and clinical significance of periostin (PN) in breast cancer and its adjacent tissues.Methods We evaluated 50 women with breast cancer.We determined PN expression by immunohistochemistry and analyzed positive expression in the tumors and adjacent tissue by paticnt age,TNM stage,SBR type,pathological type,lymph node metastasis,and other factors.Results PN expression in breast cancer and cancer adjacent tissues was associated with an increase in TNM staging (P =0.024),SBR type (P =0.012),and lymphatic metastasis (P =0.035).However,there was no significant correlation between age or pathological type (P ＞ 0.05).Condusion Expression of PN in breast cancer is associated with TNM staging,SBR type,and lymph node metastasis,and is involved in the pathological progression of breast cancer.PN may be a potential prognostic marker for breast cancer.关键词
乳腺癌/免疫组化/骨膜蛋白Key words
breast cancer/immunohistochemistry/periostin分类
医药卫生引用本文复制引用
曹宇,董文亮,刘亮,蔡相军..骨膜蛋白在乳腺癌中的表达及临床意义[J].中国医科大学学报,2017,46(7):628-631,4.基金项目
辽宁省科学技术计划(2013225089) （2013225089）
