中国医科大学学报2017，Vol.46Issue(8)：720-723,728,5.DOI:10.12007/j.issn.0258-4646.2017.08.011
肾性继发性甲状旁腺功能亢进症患者大脑影像学表现与认知功能的相关性研究
Investigation of the Relationship between Cognitive Function and MRI Manifestation in Patients with SHPT
摘要
Abstract
Objective To investigate the relationship between cognitive function and magnetic resonance imaging (MRI) manifestations in patients with secondary hyperparathyroidism (SHPT) by analyzing brain MRI diffusion-weighted imaging,diffusion tensor imaging,serological markers,and cognitive function.Methods We evaluated 49 random patients with SHPT.We adopted two functional scales to evaluate cognitive function and performed MRI fractional anisotropy (FA) and apparent diffusion coefficient (ADC) to evaluate white matter function of brain functional areas.We recorded serological markers,and conducted statistical analysis to analyze correlation among cognitive function scores,brain MRI in white matter functional areas,and biochemical parameters.Results We found that at the frontal area,the FA and ADC values were correlated with the MMSE language and memory function scores;at the parietal area,the FA and ADC values were correlated to the MoCA visuospatial executive function scores;the other areas had no significant correlation with cognitive function scale score.Cognitive function was negatively correlated with immunoreactive parathyroid hormone (iPTH) levels but positively correlated with education level,while it was not correlated with sex,age,blood pressure,and serum calcium levels in patients with SHPT.Conclusion In patients with SHPT,cognitive function is correlated with iPTH level and education level.The FA and ADC values of brain MRI in the frontal and parietal lobes might play a diagnostic role in evaluating cognitive function and locating injury for patients with SHPT,which requires clinical attention.关键词
慢性肾衰竭/甲状旁腺功能亢进症/磁共振成像/弥散加权成像/扩散张量成像/认知Key words
chronic renal failure/hyperparathyroidism/magnetic resonance imaging/diffusion weighted imaging/diffusion tensor imaging/cognition分类
医药卫生引用本文复制引用
季蓉,郝丽,张森,郑穗生,单艳棋..肾性继发性甲状旁腺功能亢进症患者大脑影像学表现与认知功能的相关性研究[J].中国医科大学学报,2017,46(8):720-723,728,5.基金项目
安徽省公益性研究联动计划项目(1604f0804021) （1604f0804021）
安徽医科大学校临床科学研究项目(2015xkj110) （2015xkj110）
