中国医科大学学报2017，Vol.46Issue(8)：724-728,5.DOI:10.12007/j.issn.0258-4646.2017.08.012
miR-608在成釉细胞瘤中的表达及意义
The Expression and Significance of miR-608 in Ameloblastoma
摘要
Abstract
Objective To study the expression and significance of miR-608 in ameloblastoma (AB).Methods Quantitative stem-loop RT-PCR was used to detect the expression of miR-608 in 26 cases of human AB (AB group) and 17 cases of peritumoural tissues (control group).The differences in miR-608 levels between the control group and the AB groups,namely,primary AB and recurrent AB,were evaluated.In addition,miR-608 levels in AB cases with different clinical and pathological characteristics were compared.Results The expression level of miR-608 in the AB group was significantly lower than that in the control group (P ＜ 0.05).Additionally,the relative expression level of miR-608 in the primary AB group was significantly lower than that in the recurrent AB group (P ＜ 0.05).There were no significant differences between the miR-608 expression levels with respet to age,gender,or pathological type (P ＞ 0.05).Conclusions The expression of miR-608 in human AB tissue is significantly decreased,which may be related to the recurrence of the tumor.关键词
成釉细胞瘤/微小核糖核酸608/实时茎环定量PCR/肿瘤复发Key words
ameloblastoma/miR-608/quantitative stem-loop RT-PCR/tumor recurrence分类
医药卫生引用本文复制引用
陈井阳,钟鸣,沈文静,刘洁..miR-608在成釉细胞瘤中的表达及意义[J].中国医科大学学报,2017,46(8):724-728,5.基金项目
国家自然科学基金(81470758) （81470758）
辽宁省教育厅科学技术研究项目(LK201626) （LK201626）
辽宁省大学生创新创业训练计划项目(201610159025) （201610159025）
