中国医科大学学报2017，Vol.46Issue(9)：769-772,4.DOI:10.12007/j.issn.0258-4646.2017.09.001
晚期糖基化终产物受体在多囊卵巢综合征大鼠模型中的表达
Expression of Receptor for Advanced Glycation End Products in a Rat Model of Polycystic Ovarian Syndrome
摘要
Abstract
Objective To investigate the expression of receptor for advanced glycation end products (RAGE) and soluble RAGE (sRAGE) in a rat model of dehydroepiandrosterone-induced polycystic ovary syndrome (PCOS) and to explore the role of sRAGE in ovarian function.Methods The PCOS rat model was established using dehydroepiandrosterone in combination with a high-fat diet.In animals with confirmed PCOS induction,serum concentrations of sRAGE and AMH were measured by competitive ELISA,and RAGE expression in ovarian tissues was detected by immunohistochemistry.Results RAGE expression was significantly higher in the PCOS group than in the control group (P ＜ 0.01).Serum concentrations of sRAGE and AMH were significantly lower and higher than those in the control group (P ＜ 0.05),respectively.Furthermore,sRAGE level was negatively correlated to that of AMH.Conclusion RAGE and sRAGE levels influence ovarian function and have substantial reference value in the diagnosis and pathogenesis of PCOS.关键词
多囊卵巢综合征/晚期糖基化终产物受体/大鼠模型Key words
polycystic ovarian syndrome/receptor for advanced glycation end products/rat model分类
医药卫生引用本文复制引用
赵彦楠,刘洪祥,马晓欣..晚期糖基化终产物受体在多囊卵巢综合征大鼠模型中的表达[J].中国医科大学学报,2017,46(9):769-772,4.基金项目
国家自然科学基金(81472438,81272874) （81472438,81272874）
辽宁省科学技术计划(2013225079) （2013225079）
沈阳市科学技术计划(F14-158-9-47) （F14-158-9-47）
盛京自由研究者基金 （）
